KLK13 / Kallikrein-13 Protein

Kallikrein-Related Peptidase 13 Protein Datasheet

KLK13 Protein Price Information

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KLK13 Protein Product Information

• KLK13 Synonym: KLK13, DKFZp586J1923, KLK-L4, KLKL4
• Protein Construction: The mature form of human KLK13 (NP_056411.1) ( Met 1- Ile 262 ) was obtained after cleavage of the C-terminal human IgG1 Fc region from the purified chimera.
• Source: Human
• Expression Host: Human Cells

KLK13 Protein QC Testing

• Purity: >95% as determined by SDS-PAGE.
• Endotoxin: < 1.0 EU per 1μg of the protein as determined by the LAL method.
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Gly 18
• Molecular Mass: The recombinant human KLK13 consists of 251 amino acids and predicts a molecular mass of 27.6 KDa. As a result of glycosylation, rhKLK13 migrates as an approximately 37 KDa band in SDS-PAGE.
• Formulation: Lyophilized from sterile filtered solution of 100mM Glycine, 10mM NaCl,50mM Tris, pH7.5
• SDS-PAGE:

KLK13 Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

KLK13 Protein Description

Human tissue kallikrein 13 (hK13), also known as KLK-L4 (kallikrein-like gene 4), is a member of the human tissue kallikrein family of serine proteases having diverse physiological functions in many tissues. The KLK13 gene resides on chromosome 19q13.3-4 along with other 14 members in a gene cluster and shares a high degree of homology. KLK13 is a trypsin-like, secreted serine protease expressed specifically in the testicular tissue including prostate, salivary gland, breast, and testis. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and may play a role in metastasis. KLK13 may be involved in the pathogenesis and/or progression of breast and ovary cancers, and is regarded as a novel cancer biomarker. In addition, KLK13 interacts and forms complexes with several serum protease inhibitors, such as alpha2-macroglobulin, and its expression is regulated by steroid hormones.

References

1. Chang A, et al., 2002, Br. J. Cancer. 86: 1457-1464.

2. Kapadia, C. et al., 2004, Biochem. Biophys. Res. Commun. 323: 1084-1090.

3. Yousef, G. M. et al., 2000, J Bio. Chem. 275: 11891 - 11898.

4. Chang, A. et al., 2002, Anticancer. Res. 21: 3147-3152.

5. Darling, M.R. et al., 2006, Int. J. Biol. Markers. 21: 106-11