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KLK13/Kallikrein 13 Protein, Antibody, ELISA Kit, cDNA Clone

KLK13/Kallikrein 13 Related Areas

KLK13/Kallikrein 13 Related Pathways

KLK13/Kallikrein 13 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    KLK13/Kallikrein 13 Summary & Protein Information

    KLK13/Kallikrein 13 Background

    Gene Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This KLK13 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    Subcellular location: Secreted (Probable).
    Tissue specificity: Expressed in prostate, breast, testis and salivary gland.
    Sequence similarity: Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.C
    General information above from UniProt

    Human tissue kallikrein 13 (hK13), also known as KLK-L4 (kallikrein-like gene 4), is a member of the human tissue kallikrein family of serine proteases having diverse physiological functions in many tissues. The KLK13 gene resides on chromosome 19q13.3-4 along with other 14 members in a gene cluster and shares a high degree of homology. KLK13 is a trypsin-like, secreted serine protease expressed specifically in the testicular tissue including prostate, salivary gland, breast, and testis. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and may play a role in metastasis. KLK13 may be involved in the pathogenesis and/or progression of breast and ovary cancers, and is regarded as a novel cancer biomarker. In addition, KLK13 interacts and forms complexes with several serum protease inhibitors, such as alpha2-macroglobulin, and its expression is regulated by steroid hormones.

    KLK13/Kallikrein 13 Alternative Name

    KLK13/Kallikrein 13 Related Studies