Anti-Kallikrein 13 Antibody

Cat: 10199-MM02
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Anti-Kallikrein 13 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Kallikrein 13 Antibody
Validated applications
WB
Species reactivity
Reacts with: Human
Specificity
Human Kallikrein 13
Immunogen
Recombinant Human KLK13 protein (Catalog#10199-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human KLK13 / Kallikrein13 (rhKLK13; Catalog#10199-H08H; NP_056411.1; Met 1-Ile 262). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG2a Clone #4B11G4C4
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Kallikrein 13 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1-2 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Kallikrein 13 Antibody Alternative Names
Anti-KLK-L4 Antibody;Anti-KLKL4 Antibody
Kallikrein 13 Background Information

Tissue kallikrein 13 (hK13), also known as KLK-L4 (kallikrein-like gene 4), is a member of the human tissue kallikrein family of serine proteases having diverse physiological functions in many tissues. The KLK13 gene resides on chromosome 19q13.3-4 along with other 14 members in a gene cluster and shares a high degree of homology. KLK13 is a trypsin-like, secreted serine protease expressed specifically in the testicular tissue including prostate, salivary gland, breast, and testis. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and may play a role in metastasis. KLK13 may be involved in the pathogenesis and/or progression of breast and ovary cancers, and is regarded as a novel cancer biomarker. In addition, KLK13 interacts and forms complexes with several serum protease inhibitors, such as alpha2-macroglobulin, and its expression is regulated by steroid hormones.

Full Name
kallikrein-related peptidase 13
References
  • Yousef G.M., et al.,(2000), Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues. J. Biol. Chem. 275:11891-11898.
  • Komatsu N., et al., (2003), Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages.J. Invest. Dermatol. 121:542-549.
  • Andres A.M., et al.,(2007), Understanding the accuracy of statistical haplotype inference with sequence data of known phase.Genet. Epidemiol. 31:659-671.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Kallikrein 13 Antibody Mouse Monoclonal ELISA 10199-MM01
    Anti-Kallikrein 13 Antibody Mouse Monoclonal ELISA(Cap) 10199-MM06
    Anti-Kallikrein 13 Antibody Rabbit Polyclonal ELISA 10199-RP01
    Anti-Kallikrein 13 Antibody Rabbit Monoclonal ELISA 10199-R001
    Anti-Kallikrein 13 Antibody Rabbit Polyclonal ELISA 10199-RP02
    Anti-Kallikrein 13 Antibody Rabbit Polyclonal ELISA 10199-T16
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