Anti-Kallikrein 13 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-Kallikrein 13 Antibody
Validated applications
WB
Species reactivity
Reacts with: Human
Specificity
Human Kallikrein 13
Immunogen
Recombinant Human KLK13 protein (Catalog#10199-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human KLK13 / Kallikrein13 (rhKLK13; Catalog#10199-H08H; NP_056411.1; Met 1-Ile 262). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG2a Clone #4B11G4C4
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Kallikrein 13 Antibody (Mouse Monoclonal antibody) Validated Applications
| Application |
Dilution |
Notes |
| WB |
1-2 μg/mL |
|
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Kallikrein 13 Antibody Alternative Names
Anti-KLK-L4 Antibody;Anti-KLKL4 Antibody
Kallikrein 13 Background Information
Tissue kallikrein 13 (hK13), also known as KLK-L4 (kallikrein-like gene 4), is a member of the human tissue kallikrein family of serine proteases having diverse physiological functions in many tissues. The KLK13 gene resides on chromosome 19q13.3-4 along with other 14 members in a gene cluster and shares a high degree of homology. KLK13 is a trypsin-like, secreted serine protease expressed specifically in the testicular tissue including prostate, salivary gland, breast, and testis. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and may play a role in metastasis. KLK13 may be involved in the pathogenesis and/or progression of breast and ovary cancers, and is regarded as a novel cancer biomarker. In addition, KLK13 interacts and forms complexes with several serum protease inhibitors, such as alpha2-macroglobulin, and its expression is regulated by steroid hormones.
Full Name
kallikrein-related peptidase 13
References
Yousef G.M., et al.,(2000), Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues. J. Biol. Chem. 275:11891-11898.Komatsu N., et al., (2003), Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages.J. Invest. Dermatol. 121:542-549.Andres A.M., et al.,(2007), Understanding the accuracy of statistical haplotype inference with sequence data of known phase.Genet. Epidemiol. 31:659-671.
