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>Human Cell Expressed
>Rat KIT / c-KIT Protein (His Tag) (Receptor Tyrosine Kinase)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Protein Datasheet
KIT / c-KIT Protein Price Inquiry ( Available Sizes )
KIT / c-KIT Protein Product Information
A DNA sequence encoding the rat KIT (Q63116)(Met1-Thr522) was expressed, fused with a polyhistidine tag at the C-terminus.
|Expression Host:||Human Cells|
KIT / c-KIT Protein QC Testing
|Purity:||> 95 % as determined by SDS-PAGE||SDS-PAGE:
KIT / c-KIT protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Ser 25|
The recombinant rat KIT comprises 509 amino acids and predicts a molecular mass of 56.9 kDa. The apparent molecular mass of the recombinant protein is approximately 83 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
KIT / c-KIT Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
KIT / c-KIT Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|c-Kit/CD117||Human||c-kit/CD117 Protein, Recombinant||11996-H08H|
|c-Kit/CD117||Human||KIT / c-KIT / CD117 (aa 540-972) Protein, Recombinant, GST Tag||11996-H20B1|
|c-Kit/CD117||Mouse||c-kit/CD117/Fc Protein, Recombinant||50530-M02H|
|c-Kit/CD117||Mouse||c-kit/CD117 Protein, Recombinant||50530-M08H|
|c-Kit||Rat||KIT / c-KIT Protein, Recombinant||80321-R02H|
|c-Kit||Rat||KIT / c-KIT Protein, Recombinant||80321-R08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human c-Kit/CD117||WB, ELISA||c-Kit / CD117 / KIT Antibody (Antigen Affinity Purified)||11996-RP02|
|Mouse c-Kit/CD117||WB, ELISA||c-Kit / CD117 / KIT Antibody||50530-RP01|
|Mouse c-Kit/CD117||WB, ELISA||c-Kit / CD117 / KIT Antibody (Antigen Affinity Purified)||50530-RP02|
KIT / c-KIT Protein Description
Mast / stem cell growth factor receptor, also known as Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, CD117 and KIT, is a single-pass type I membrane protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. CD117 / KIT contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 / KIT is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K). CD117 is the receptor for the cytokine stem cell factor (SCF), when this receptor binds to SCF it forms a dimer that activates signaling through second messengers. Signaling through CD117 plays a role in cell survival, proliferation, and differentiation. Defects in CD117 / KIT are a cause of piebaldism which is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. Defects in CD117 / KIT have also been associated with testicular tumors (TEST) which is a common solid malignancy in males.
- Fleischman RA. et al., 1992, J Clin Invest. 89:1713-7.
- Spritz RA. et al., 1992, Am J Hum Genet. 50:261-9.
- Syrris P. et al., 2000, Am J Med Genet. 95:79-81.
- Leong KG. et al., 2008, Nature. 456 (7223): 804.