KIRREL3 / NEPH2 Protein & Antibody

Kin of IRRE Like 3 / Nephrin-like 2

KIRREL3 / NEPH2 Products

KIRREL3 / NEPH2 Protein, Recombinant

Molecule	Species	Description	Cat. No
KIRREL3/NEPH2	Mouse	KIRREL3/NEPH2 Protein, Recombinant	50339-M08H

KIRREL3 / NEPH2 Antibody

Molecule	Application	Description	Cat. No
Mouse KIRREL3 / NEPH2	WB, ELISA	KIRREL3 / NEPH2 Antibody (Antigen Affinity Purified)	50339-RP02

KIRREL3 / NEPH2 cDNA Clone

Molecule	Species	Description	Cat. No
KIRREL3 / NEPH2	Rat	KIRREL3 cDNA Clone / ORF Clone	RG80225-G

KIRREL3 / NEPH2 Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>KIRREL3/NEPH2

KIRREL3 / NEPH2 Alternative Names

KIRREL3, NEPH2, UNQ5923/PRO4502/PRO19814, KIAA1867, KIRRE, MGC126824, MGC126850, MRD4, NEPH2, PRO4502 [Homo sapiens]

Kirrel3, NEPH2, 1500010O20Rik, 2900036G11Rik, SST4, mKIAA1867 [Mus musculus]

KIRREL3 / NEPH2 Background

Kin of IRRE-like protein 3 (KIRREL3) also known as nin of irregular chiasm-like protein 3 or nephrin-like protein 2 (NEPH2) is a member of the nephrin-like protein family of transmembrane proteins, which includes NEPH1 (KIRREL) and NEPH3 (KIRREL2). KIRREL3/NEPH2 is expressed in fetalv and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of KIRREL3/NEPH2 interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in KIRREL3/NEPH2 are associated with mental retardation autosomal dominant type 4. KIRREL3/NEPH2 expression is turned on in migrating nucleogenesis of the pontine nucleus (PN) neurons only after they enter the presumptive nuclear region. KIRREL3/NEPH2 knockdown disrupted the nuclear organization of PN presumably by changing the migratory behavior of PN neurons inside the nuclear region. Moreover, overexpression of the cytoplasmic region of KIRREL3, which can sequester intracellular signaling of endogenous KIRREL3, resulted in similar phenotypes. Overall, these results suggest KIRREL3 is involved in the nucleogenesis of the PN through the control of neuronal migration inside the nucleus.

KIRREL3 / NEPH2 Related Studies

1. Bhalla K, et al. (2008) Alterations in CDH15 and KIRREL3 in patients with mild to severe intellectual disability. Am J Hum Genet. 83(6): 703-13.
2. Gerke P, et al. (2005) NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. J Am Soc Nephrol. 16(6): 1693-702.
3. Gerke P, et al. (2006) Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. J Comp Neurol. 498(4): 466-75.