Anti-KIR2DL1 Antibody

Cat: 13145-T16
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Anti-KIR2DL1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-KIR2DL1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human KIR2DL1
Immunogen
Recombinant Human KIR2DL1 / CD158a protein (Catalog#13145-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human KIR2DL1 / CD158a (rh KIR2DL1 / CD158a; Catalog#13145-H08H; NP_055033.2; Met1-His245). KIR2DL1 / CD158a specific IgG was purified by Human KIR2DL1 / CD158a affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-KIR2DL1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-KIR2DL1 Antibody Alternative Names
Anti-CD158A Antibody;Anti-KIR-K64 Antibody;Anti-KIR221 Antibody;Anti-NKAT Antibody;Anti-NKAT-1 Antibody;Anti-NKAT1 Antibody;Anti-p58.1 Antibody;Anti-XXbac-BPG184J6.7 Antibody
KIR2DL1 Background Information

Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and in KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and in a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal.

Full Name
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
References
  • Fan QR, et al. (2001) Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nature Immunology. 2: 452-60.
  • Wagtmann N, et al. (1995) Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity. 2 (5): 439-49.
  • Colonna M, et al. (1995) Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science. 268 (5209): 405-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-KIR2DL1 Antibody (PerCP) Rabbit Monoclonal FCM 13145-R124-C
    Anti-KIR2DL1 Antibody (PE) Rabbit Monoclonal FCM 13145-R124-P
    Anti-KIR2DL1 Antibody Mouse Monoclonal ELISA 13145-MM07
    Anti-KIR2DL1 Antibody (APC) Rabbit Monoclonal FCM 13145-R124-A
    Anti-KIR2DL1 Antibody Rabbit Polyclonal ELISA 13145-RP01
    Anti-KIR2DL1 Antibody (FITC) Rabbit Monoclonal FCM 13145-R124-F
    Anti-KIR2DL1 Antibody Rabbit Monoclonal FCM 13145-R124
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