**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and in KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and in a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal.
|Product Description||Host||Clonality||Application||Catalog# (PDF)|
|Anti-KIR2DL1 Antibody (PerCP)||Rabbit||Monoclonal||FCM||13145-R124-C|
|Anti-KIR2DL1 Antibody (PE)||Rabbit||Monoclonal||FCM||13145-R124-P|
|Anti-KIR2DL1 Antibody (APC)||Rabbit||Monoclonal||FCM||13145-R124-A|
|Anti-KIR2DL1 Antibody (FITC)||Rabbit||Monoclonal||FCM||13145-R124-F|