TIM1 (KIM-1, HACVR1)

Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM1), is a type â… integral membrane glycoprotein. TIM1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of TIM1 protein and that their association has a synergistic effect in virus-receptor interactions. TIM1 involves in the pathogenesis of acute kidney injury. It had been confirmed that TIM1 is a human urinary renal dysfunction biomarker. Moreover, TIM1 protein is a novel regulatory molecule of flow-induced calcium signaling.

TIM1 (KIM-1, HACVR1) Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>KIM-1/TIM1/HAVCR1

TIM1 (KIM-1, HACVR1) Alternative Names

HAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM-1, TIM1, TIMD1, TIM; TIMD-1 [Homo sapiens]

Havcr1, RP23-31K14.2, AI503787, TIM-1, Tim1, Timd1, HAVcr-1, TIMD-1 [Mus musculus]

Havcr1, KIM-1, Kim1, HAVcr-1; TIMD-1 [Rattus norvegicus]

HAVCR1 [Canis lupus familiaris]

Summaries for TIM1 (KIM-1, HACVR1)

Entrez Gene summary for HACVR1:

The protein encoded by this HACVR1 gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. TIM1 may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

Wikipedia summary for TIM1:

Hepatitis A virus cellular receptor 1 is a protein that in humans is encoded by the HAVCR1 gene

Human TIM1 (KIM-1, HACVR1) Protein General Information

 

• Protein names: T-cell membrane protein 1, TIM-1
• Sequence length: 359 AA.
• Induction: Up-regulated in the kidney in renal diseases (at protein level).
• Sequence similarities: TIM1 belongs to the immunoglobulin superfamily. TIM family. TIM1 contains 1 Ig-like V-type (immunoglobulin-like) domain.
• Polymorphism: Infection by hepatitis A virus (HAV) protects individuals from atopy if they carry insertion of the variants Met-Thr-Thr-Val-Pro-157 and Met-Thr-Thr-Thr-Val-Pro-157. Modernisation has led to a reduction in HAV seroprevalence and thus, may be, to an increase of expression of atopy, such as asthma, allergic rhinitis and atopic dermatitis. Allelic variation does not affect HAV-infection rates in Caucasians, Asians and African Americans.
• Miscellaneous: The extracellular part of the protein can be cleaved and detected in urine and is in correlation with the expression in the kidney.
• Subcellular location: Membrane; Single-pass type I membrane protein
• Tissue specificity: TIM1 is widely expressed, with highest levels in kidney and testis. TIM1 is expressed by activated CD4+ T-cells during the development of helper T-cells responses.

General information above from UniProt

Function for TIM1 (KIM-1, HACVR1) Protein

UniProtKB:

TIM1 may play a role in T-helper cell development and the regulation of asthma and allergic diseases. TIM1 is receptor for TIMD4. In case of human hepatitis A virus (HHAV) infection, TIM1 functions as a cell-surface receptor for the virus. TIM1 may play a role in kidney injury and repair.

Genatlas:

• TIM1 has a possible role in cell adhesion
• TIM1 is putative adhesion protein involved in renal regeneration
• TIM1plays a role in T helper cell development and the regulation of asthma and allergic diseases
• TIM1 is phosphatidylserine receptors for the engulfment of apoptotic cells, and may also be involved in intercellular signaling in which exosomes are involved
• TIM1 is endogenous ciliary receptor which interacts with PKD2
• TIM1 is recruited to the TCR-signaling complex via association with CD3 (Pubmed 17371991)
• TIM1 is critical component of the human T cell response (Pubmed 17371991)
• HAVCR1-signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation (Pubmed 21303660)
• TIM1 may be involved in the differentiation of B cells to plasma cells (Pubmed 21303660)

Homology for human TIM1 (KIM-1, HACVR1)

• ortholog to murine Havcr1

Phenotype Information for TIM1 (KIM-1, HACVR1)

• Gene/Locus: HAVCR1, HAVCR
• Phenotype: {Atopy, resistance to}

Phenotype Information for TIM1 from OMIM (Online Mendelian Inheritance in Man)