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TIM-1/KIM-1/HACVR  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
11051-HNCH-50
11051-HNCH-100
50 µg 
100 µg 
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Expression host: Human Cells  
11051-H16H-50
11051-H16H-100
50 µg 
100 µg 
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Expression host: Human Cells  
11051-H08H1-50
11051-H08H1-100
50 µg 
100 µg 
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Expression host: Human Cells  
11051-H07H-50
11051-H07H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50321-M16H-50
50321-M16H-100
50 µg 
100 µg 
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Expression host: Human Cells  
50321-M07H-50
50321-M07H-100
50 µg 
100 µg 
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Expression host: Human Cells  
80003-R16H-20
80003-R16H-100
20 µg 
100 µg 
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Expression host: Human Cells  
80003-R07H-50
80003-R07H-100
50 µg 
100 µg 
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Expression host: Human Cells  
70001-D04H-50
70001-D04H-200
50 µg 
200 µg 
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Expression host: Human Cells  
70001-D07H-50
70001-D07H-100
50 µg 
100 µg 
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Expression host: Human Cells  
90006-C07H-50
90006-C07H-100
50 µg 
100 µg 
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Expression host: Human Cells  
90006-C08H-50
90006-C08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
90006-CNCH1-50
90006-CNCH1-100
50 µg 
100 µg 
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TIM-1/KIM-1/HACVR Related Area

TIM-1/KIM-1/HACVR Related Pathways

    TIM-1/KIM-1/HACVR Summary & Protein Information

    TIM-1/KIM-1/HACVR Background

    Gene Summary: The protein encoded by this HACVR1 gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. TIM1 may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
    General information above from NCBI
    Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
    Tissue specificity: Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. {ECO:0000269|PubMed:9658108}.
    Induction: Up-regulated in the kidney in renal diseases (at protein level). {ECO:0000269|PubMed:17471468}.
    Sequence similarity: Belongs to the immunoglobulin superfamily. TIM family. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â…  integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.

    TIM-1/KIM-1/HACVR Alternative Name

    TIM-1/KIM-1/HACVR Related Studies

  • Tami C, et al. (2007) Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 81(7): 3437-46.
  • Rees AJ, et al. (2008) Kim-1/Tim-1: from biomarker to therapeutic target? Nephrol Dial Transplant. 23(11): 3394-6.
  • Chaturvedi S, et al. (2009) Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci. 5(2): 128-34.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"