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KIM-1 / TIM1 / HACVR1 Antibody, Mouse MAb

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Human KIM1/TIM1 Antibody Product Information
Immunogen:Recombinant Human HAVCR1 protein (Catalog#11051-H08H1)
Clone ID:12B1C8H3
Ig Type:Mouse IgG1
Concentration:
Formulation:
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human HAVCR1 (rh HAVCR1; Catalog#11051-H08H1; AAC39862.1; Met 1-Val 135). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human KIM1/TIM1 Antibody Usage Guide
Specificity:Human HAVCR1 / TIM1 / KIM1
No cross-reactivity in WB and ELISA with
Rat KIM1 / HAVCR1 / TIM1
MouseKIM1 / HAVCR1 / TIM1
CanineKIM1 / HAVCR1 / TIM1
Application:WB

WB: 1-2 μg/mL

This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human KIM1 in WB. Using a DAB detection system, the detection limit for Human KIM1 is approximately 100 ng/lane under non-reducing conditions and 8 ng/lane under reducing conditions.

Storage:
Other KIM1/TIM1 Antibody Products
KIM-1/TIM1/HACVR1 Background

Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â…  integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.

Human KIM-1/TIM1/HACVR1 References
  • Tami C, et al. (2007) Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 81(7): 3437-46.
  • Rees AJ, et al. (2008) Kim-1/Tim-1: from biomarker to therapeutic target? Nephrol Dial Transplant. 23(11): 3394-6.
  • Chaturvedi S, et al. (2009) Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci. 5(2): 128-34.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"