|Recombinant Human HAVCR1 protein (Catalog#11051-H08H1)|
|This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human HAVCR1 (rh HAVCR1; Catalog#11051-H08H1; AAC39862.1; Met 1-Val 135). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.|
|Human HAVCR1 / TIM1 / KIM1
No cross-reactivity in WB and ELISA with
Rat KIM1 / HAVCR1 / TIM1
MouseKIM1 / HAVCR1 / TIM1
CanineKIM1 / HAVCR1 / TIM1
WB: 1-2 μg/mL
This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human KIM1 in WB. Using a DAB detection system, the detection limit for Human KIM1 is approximately 100 ng/lane under non-reducing conditions and 8 ng/lane under reducing conditions.
Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.