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Rat VEGFR2 / Flk-1 / CD309 / KDR Protein (Fc Tag)
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Rat VEGFR2 / Flk-1 / CD309 / KDR Protein (Fc Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
80113-R02H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Kinase insert domain receptor Protein Datasheet

 

KDR / VEGFR2 / CD309 Protein Price Inquiry ( Available Sizes )

KDR / VEGFR2 / CD309 Protein Product Information

Synonym : KDR
Protein Construction:

A DNA sequence encoding the rat KDR (Q5PQU0) (Met1-Glu760) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Source: Rat
Expression Host: Human Cells

KDR / VEGFR2 / CD309 Protein QC Testing

Purity: > 95% as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

KDR / VEGFR2 / CD309 protein

Bio-activity:

Immobilized mouse VEGF164 (Cat:50159-MNAB) at 10 μg/ml (100 μl/well) can bind rat KDR-Fc, The EC50 of rat KDR-Fc is 0.07-0.15 μg/ml.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Ala 20
Molecular Mass:

The recombinant rat KDR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 982 amino acids and has a predicted molecular mass of 110 kDa. The apparent molecular mass of the protein is approximately 120 kDa in SDS-PAGE under reducing conditions.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

KDR / VEGFR2 / CD309 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

KDR / VEGFR2 / CD309 Protein Related Products & Topics

Related Areas:

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
VEGFR2/Flk-1/CD309 Human VEGFR2/Flk-1/CD309/Fc Protein, Recombinant 10012-H02H
VEGFR2/Flk-1/CD309 Human VEGFR2 / Flk-1 / CD309 Protein, Recombinant 10012-H08H
VEGFR2/Flk-1/CD309 Human KDR / VEGFR2 / CD309 Protein, Recombinant, with GST Tag 10012-H20B1
VEGFR2/Flk-1/CD309 Mouse KDR / VEGFR2 / CD309 Protein, Recombinant 50998-M02H
VEGFR2/Flk-1/CD309 Mouse KDR / VEGFR2 / CD309 Protein, Recombinant 50998-M08H
VEGFR2/Flk-1/CD309 Rat KDR / VEGFR2 / CD309 Protein, Recombinant 80113-R02H
VEGFR2/Flk-1/CD309 Rat KDR / VEGFR2 / CD309 Protein, Recombinant 80113-R08H

Antibodies:

KDR / VEGFR2 / CD309 Protein Description

Vascular endothelial cell growth factor (VEGF), also known as vascular permeability factor, is an endothelial cell mitogen, which stimulates angiogenesis by binding to specific receptors (VEGFRs) on the surface of vascular endothelial cells. The VEGF ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. All the three receptors for VEGF, VEGFR1~3, belong to CSF-1/PDGF receptor subfamily of receptor tyrosine kinase superfamily (RTKs), and contains seven Ig-like C2-type domains in the ECD, as well as a intracellular protein kinase domain. VEGFR2, also called as KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. The adaptor protein SHB has been shown to interact with VEGFR2 in receptor tyrosine kinase signaling. In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.

References

  1. Terman BI. et al., 1992, Biochem Biophys Res Commun. 187: 1579-86.
  2. McTigue MA. et al., 1999, Structure. 7: 319-30.
  3. Patterson C. et al., 1995, J Biol Chem. 270: 23111-8.
  4. Holmqvist K. et al., 2004, J Biol Chem. 279: 22267-75.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"