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Junctional Adhesion Molecule A  Antibody

All F11R Reagents

Reactivity: Human  
Application: ELISA  
10198-MM02-50
10198-MM02-200
10198-MM02-100
10198-MM02-1
50 µg 
200 µg 
100 µg 
1 mg 
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    Reactivity: Human  
    Application: FCM  
    10198-MM04-F-25
    10198-MM04-F-100
    25 Test 
    100 Tests 
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    • Slide 1
    Reactivity: Human  
    Application: ELISA  
    10198-RP01-400
    10198-RP01-200
    10198-RP01-100
    400 µg 
    200 µg 
    100 µg 
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      Reactivity: Human  
      Application: ELISA  WB  IP  
      10198-RP04-50
      10198-RP04-200
      10198-RP04-100
      50 µg 
      200 µg 
      100 µg 
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      • Slide 1
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      Reactivity: Human  
      Application: FCM  
      10198-MM04-A-25
      10198-MM04-A-100
      25 Test 
      100 Tests 
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      • Slide 1
      Reactivity: Human  
      Application: 
      10198-MM08-50
      10198-MM08-200
      10198-MM08-100
      10198-MM08-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
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        Reactivity: Human  
        Application: FCM  IF  ICC/IF  
        10198-MM04-50
        10198-MM04-200
        10198-MM04-100
        50 µg 
        200 µg 
        100 µg 
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        • Slide 1
        • Slide 1
        Reactivity: Human  
        Application: FCM  
        10198-MM04-P-25
        10198-MM04-P-100
        25 Test 
        100 Tests 
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        • Slide 1

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        Junctional Adhesion Molecule A Related Pathways

          Junctional Adhesion Molecule A Summary & Protein Information

          Junctional Adhesion Molecule A Background

          Gene Summary: OMIM - description for Junctional Adhesion Molecule A :
          General information above from NCBI
          Subunit structure: Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein (By similarity). {ECO:0000250}.
          Subcellular location: Cell junction, tight junction {ECO:0000269|PubMed:11171323}. Cell membrane {ECO:0000269|PubMed:11171323}; Single-pass type I membrane protein {ECO:0000269|PubMed:11171323}. Note=Localized at tight junctions of both epithelial and endothelial cells.
          Post-translational: N-glycosylated. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7646439}.
          Sequence similarity: Belongs to the immunoglobulin superfamily. {ECO:0000305}.; Contains 2 Ig-like V-type (immunoglobulin-like) domains. {ECO:0000305}.
          General information above from UniProt

          Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.

          Junctional Adhesion Molecule A Alternative Name

          Junctional Adhesion Molecule A Related Studies

        • Guglielmi KM, et al. (2007) Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem. 282(24): 17930-40.
        • Yeung D, et al. (2008) Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown. Acta Neuropathol. 115(6): 635-42.
        • Ong KL, et al. (2009) Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension. Am J Hypertens. 22(5): 500-5.
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