JNK2 (Protein|Antibody|cDNA Clone|ELISA Kit)

All JNK2 reagents are produced in house and quality controlled, including 9 JNK2 Antibody, 30 JNK2 Gene, 5 JNK2 IPKit, 1 JNK2 Lysate, 1 JNK2 Protein, 2 JNK2 qPCR. All JNK2 reagents are ready to use.

Recombinant JNK2 proteins are expressed by Baculovirus-Insect Cells with fusion tags as C-His.

JNK2 antibodies are validated with different applications, which are WB, ELISA, IP, ICC/IF, IF, FCM, IHC-P.

JNK2 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each JNK2 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

JNK2 Protein (1)

Species

JNK2 Protein, Human, Recombinant (His Tag)

10745-H08B

Expression host: Baculovirus-Insect Cells

Human JNK2/MAPK9 Protein 9081
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JNK2 Antibody (9)

Application Clonality
Host

Anti-JNK2 Antibody

100961-T02

Specificity: Human

Application: ICC/IF,IF

Clonality: PAb

Human JNK2/MAPK9 Immunofluorescence(IF) 14590

Anti-JNK2 Antibody

10745-T20

Specificity: Human

Application: ELISA,IP

Clonality: PAb

Human JNK2/MAPK9 Immunoprecipitation(IP) 6024

Anti-JNK2 Antibody

10745-R004

Specificity: Human

Application: WB,ELISA,ICC/IF,IF,IP

Clonality: MAb

Human JNK2/MAPK9 Immunofluorescence(IF) 2885

Anti-JNK2 Antibody

100961-T10

Specificity: Human

Application: IHC-P,ICC/IF,IF

Clonality: PAb

Human JNK2/MAPK9 Immunohistochemistry(IHC) 17297

Anti-JNK2 Antibody

10745-MM01

Specificity: Human

Application: WB,ELISA,IP

Clonality: MAb

Human Latexin Immunoprecipitation(IP) 7956

Anti-JNK2 Antibody

10745-RP02

Specificity: Human

Application: ELISA,IP

Clonality: PAb

Human JNK2/MAPK9 Immunoprecipitation(IP) 8016

Anti-JNK2 Antibody

10745-MM06

Specificity: Human

Application: FCM,ICC/IF,IF

Clonality: MAb

Human JNK2/MAPK9 Immunofluorescence(IF) 2887

Anti-JNK2 Antibody

10745-R011

Specificity: Human

Application: WB,ELISA,IHC-P,ICC/IF,IF,IP

Clonality: MAb

Human JNK2/MAPK9 Immunofluorescence(IF) 2886

Anti-JNK2 Antibody

10745-RP01

Specificity: Human

Application: ELISA

Clonality: PAb

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JNK2 cDNA Clone (30)

Mouse
Human

JNK2 qPCR Primer (2)

JNK2 IP Kit (5)

JNK2 Lysate (1)

Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, such as c-Jun and ATF2. The crystal structure of human JNK2 complexed with an indazole inhibitor by applying a high-throughput protein engineering and surface-site mutagenesis approach. A novel conformation of the activation loop is observed, which is not compatible with its phosphorylation by upstream kinases. This activation inhibitory conformation of JNK2 is stabilized by the MAP kinase insert that interacts with the activation loop in an induced-fit manner. It suggest that the MAP kinase insert of JNK2 plays a role in the regulation of JNK2 activation, possibly by interacting with intracellular binding partners. JNK2 deficiency leads to reduced c-Jun degradation, thereby augmenting c-Jun levels and cellular proliferation, and suggests that JNK2 is a negative regulator of cellular proliferation in multiple cell types. JNK2 prevents replicative stress by coordinating cell cycle progression and DNA damage repair mechanisms. JNK2 blocks the ubiquitination of tumor suppressor p53, and thus increases the stability of p53 in nonstressed cells. JNK2 negatively regulates antigen-specific CD8+ T cell expansion and effector function, and thus selectively blocking JNK2 in CD8+ T cells may potentially enhance anti-tumor immune response. Lack of JNK2 expression was associated with higher tumor aneuploidy and reduced DNA damage response. Additionally,the JNK2 protein could be a novel therapeutic target in dry eye disease, and may provide a novel target for prevention of vascular disease and atherosclerosis.
Protein
Antibody
Gene
qPCR
IPKit
Lysate
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