+86-400-890-9989
Product Catalog
> JNK1 Protein (MAPK8 Protein) JNK1 Protein (MAPK8 Protein)
c-Jun N-terminal Kinase 1 (Mitogen-Activated Protein Kinase 8)
JNK1 Products
JNK1 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| JNK1/MAPK8 | Human | JNK1/MAPK8 Protein, Recombinant | 10795-H09B |
JNK1 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| JNK1/MAPK8 | Human | Homo sapiens JNK1/MAPK8 cDNA Clone(NM_139047.1) | HG10795-M |
| JNK1/MAPK8 | Mouse | Mus musculus JNK1/MAPK8 cDNA Clone | MG50009-M |
JNK1 Related Areas
Enzyme>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>JNK1/MAPK8
Neuroscience>>Axon Guidance>>Wnt Signaling Pathway>>JNK1/MAPK8
Signal Transduction>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>JNK1/MAPK8
Signal Transduction>>Wnt Signaling Pathway>>Non-Canonical Wnt Pathway>>JNK1/MAPK8
Stem Cell>>Wnt Signaling Pathway>>Non-Canonical Wnt Pathway>>JNK1/MAPK8
JNK1 Alternative Names
JNK1, MAPK8, JNK-46, stress-activated protein kinase 1, stress-activated protein kinase JNK1 JNK, JNK1A2, JNK21B1/2, PRKM8, SAPK1 [Homo sapiens]
JNK1, JNK, Mapk8, Prkm8, SAPK1, stress-activated protein kinase JNK1, AI849689 [Mus musculus]
JNK1 Related Products
Protein Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| ERK2/MAPK1/MAPK2 | Human | ERK2/MAPK1 Protein, Recombinant, With GST Tag |
| JNK2/MAPK9 | Human | JNK2/MAPK9 Protein, Recombinant |
| p38 delta/MAPK13 | Human | p38 delta/MAPK13 Protein, Recombinant, with GST Tag |
| p38 alpha/MAPK14 | Human | p38 alpha/MAPK14 Protein, Recombinant |
| p38 alpha/MAPK14 | Human | p38 alpha/MAPK14 Protein, Recombinant |
| p38 alpha/MAPK14 | Human | p38 alpha/MAPK148 Protein, Recombinant |
| MAPKAPK3 | Human | MAPKAPK3 Protein, Recombinant |
cDNA Clone Products
JNK1 Background
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The protein kinases JNK1 has been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. It is critically involved in the promotion of diet-induced obesity, metabolic inflammation, insulin resistance, and beta-cell dysfunction. The selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. JNK1 is also implicated in the mechanism of obesity-induced insulin resistance. Genetic analysis indicates that the effects of JNK1 on insulin resistance can be separated from effects of JNK1 on obesity. Emerging research indicates that JNK1 plays multiple roles in the regulation of insulin resistance, including altered gene expression, hormone/cytokine production, and lipid metabolism. JNK1 is a potential pharmacological target for the development of drugs that might be useful for the treatment of insulin resistance, metabolic syndrome, and type 2 diabetes. Furthermore, JNK1 plays a major role in the hypoxic cellular damage. JNK1 protein might be an attractive target for antihypoxic therapy in increasing resistance to many pathological conditions and diseases, leading to the oxygen deficit.
JNK1 Related Studies
- Betigeri S, et al. (2006) JNK1 as a molecular target to limit cellular mortality under hypoxia. Mol Pharm. 3(4): 424-30.
- Sabio G, et al. (2010) cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends Biochem Sci. 35(9): 490-6.
- Solinas G, et al. (2010) JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J. 24(8): 2596-611.
- Sabio G, et al. (2010) Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev. 24(3): 256-64.
