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JNK1 Protein (MAPK8 Protein)

c-Jun N-terminal Kinase 1 (Mitogen-Activated Protein Kinase 8)

JNK1 Products

JNK1 Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
JNK1/MAPK8 Human JNK1/MAPK8 Protein, Recombinant 10795-H09B

JNK1 cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
JNK1/MAPK8 Human Homo sapiens JNK1/MAPK8 cDNA Clone(NM_139047.1) HG10795-M
JNK1/MAPK8 Mouse Mus musculus JNK1/MAPK8 cDNA Clone MG50009-M

JNK1 Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>JNK1/MAPK8

Neuroscience>>Axon Guidance>>Wnt Signaling Pathway>>JNK1/MAPK8

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>JNK1/MAPK8

Signal Transduction>>Wnt Signaling Pathway>>Non-Canonical Wnt Pathway>>JNK1/MAPK8

Stem Cell>>Wnt Signaling Pathway>>Non-Canonical Wnt Pathway>>JNK1/MAPK8

JNK1 Alternative Names

JNK1, MAPK8, JNK-46, stress-activated protein kinase 1, stress-activated protein kinase JNK1 JNK, JNK1A2, JNK21B1/2, PRKM8, SAPK1 [Homo sapiens]

JNK1, JNK, Mapk8, Prkm8, SAPK1, stress-activated protein kinase JNK1, AI849689 [Mus musculus]

JNK1 Related Products

Protein Products

Molecule Species Description //For Detailed Info. and Price------CLICK!
ERK2/MAPK1/MAPK2 Human ERK2/MAPK1 Protein, Recombinant, With GST Tag
JNK2/MAPK9 Human JNK2/MAPK9 Protein, Recombinant
p38 delta/MAPK13 Human p38 delta/MAPK13 Protein, Recombinant, with GST Tag
p38 alpha/MAPK14 Human p38 alpha/MAPK14 Protein, Recombinant
p38 alpha/MAPK14 Human p38 alpha/MAPK14 Protein, Recombinant
p38 alpha/MAPK14 Human p38 alpha/MAPK148 Protein, Recombinant
MAPKAPK3 Human MAPKAPK3 Protein, Recombinant

cDNA Clone Products

Molecule Species Description //For Detailed Info. and Price------CLICK!
ERK2/MAPK1/MAPK2 Human Homo sapiens ERK2 transcript variant 1 cDNA Clone(NM_002745.4)
ERK3/MAPK6 Human Homo sapiens ERK3 cDNA Clone(NM_002748.2)
ERK5/BMK1/MAPK7 Human Homo sapiens ERK5/BMK1 transcript variant 3 cDNA Clone(NM_002749.2)
JNK2/MAPK9 Human Homo sapiens JNK2/MAPK9 cDNA Clone(NM_002752.4)
p38 delta/MAPK13 Human Homo sapiens p38 delta/MAPK13 cDNA Clone(NM_002754.3)
p38 alpha/MAPK14 Human Homo sapiens p38 alpha/MAPK14 cDNA Clone(NM_139012.1)
p38 alpha/MAPK14 Human Homo sapiens p38 alpha/MAPK14 cDNA Clone(NM_001315.2)
MEK2/MKK2/MAP2K2 Human Homo sapiens MEK2/MKK2/MAP2K2 cDNA Clone(NM_030662.3)
MKK6/MEK6/MAP2K6 Human Homo sapiens MKK6/MEK6/MAP2K6 cDNA Clone(NM_002758.3)
MEKK3/MAP3K3/MAPKKK3 Human Homo sapiens MEKK3/MAP3K3 cDNA Clone(NM_002401.3)
TPL2/MAP3K8/MEKK8 Human Homo sapiens TPL2/MAP3K8 cDNA Clone(NM_005204.2)
MAPKAPK3 Human Homo sapiens MAPKAPK3 cDNA Clone(NM_004635.3)
MNK1/MKNK1 Human Homo sapiens MNK1/MKNK1 transcript variant 2 cDNA Clone(NM_001135553.1)
MNK1/MKNK1 Human Homo sapiens MNK1/MKNK1 transcript variant 3 cDNA Clone(NM_198973.2)

JNK1 Background

Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The protein kinases JNK1 has been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. It is critically involved in the promotion of diet-induced obesity, metabolic inflammation, insulin resistance, and beta-cell dysfunction. The selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. JNK1 is also implicated in the mechanism of obesity-induced insulin resistance. Genetic analysis indicates that the effects of JNK1 on insulin resistance can be separated from effects of JNK1 on obesity. Emerging research indicates that JNK1 plays multiple roles in the regulation of insulin resistance, including altered gene expression, hormone/cytokine production, and lipid metabolism. JNK1 is a potential pharmacological target for the development of drugs that might be useful for the treatment of insulin resistance, metabolic syndrome, and type 2 diabetes. Furthermore, JNK1 plays a major role in the hypoxic cellular damage. JNK1 protein might be an attractive target for antihypoxic therapy in increasing resistance to many pathological conditions and diseases, leading to the oxygen deficit.

JNK1 Related Studies

  1. Betigeri S, et al. (2006) JNK1 as a molecular target to limit cellular mortality under hypoxia. Mol Pharm. 3(4): 424-30.
  2. Sabio G, et al. (2010) cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends Biochem Sci. 35(9): 490-6.
  3. Solinas G, et al. (2010) JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J. 24(8): 2596-611.
  4. Sabio G, et al. (2010) Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev. 24(3): 256-64.

 

JNK1 related areas, pathways, and other information

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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