JAML Protein & Antibody (AMICA1)

Junctional Adhesion Molecule-Like (Adhesion Molecule, Interacts with CXADR Antigen 1)

JAML Products

JAML Protein, Recombinant

Molecule	Species	Description	Cat. No
JAML/AMICA1	Human	JAML/AMICA1 Protein, Recombinant	10120-H08H

  10120-H08H: When 5 x 10⁴ cells/well are added to JAML coated plates (10 µg/mL and 100 µL/well), approximately 32% will adhere specifically after 60 minutes at 37℃. Measured by the ability of the immobilized protein to support the adhesion of HeLa human cervical epithelial carcinoma cells.

JAML Antibody

Molecule	Application	Description	Cat. No
Human JAML/AMICA1	WB, ELISA	JAML/AMICA1 Antibody, Rabbit PAb	10120-RP01
Human JAML/AMICA1	WB, ELISA	JAML/AMICA1 Antibody, Rabbit PAb (Antigen Affinity Purified)	10120-RP02

JAML cDNA Clone

Molecule	Species	Description	Cat. No
JAML/AMICA1	Human	Homo sapiens JAML/AMICA1 transcript variant 1 cDNA Clone(NM_001098526.1)	HG10120-M

JAML Alternative Names

JAML, AMICA1, AMICA, Gm638, CREA7-1, CREA7-4, FLJ37080, MGC118814, MGC118815

JAML Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>JAML/AMICA1

JAML Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
JAM-A/F11R/CD321	Human	JAM-A/F11R/Fc Protein, Recombinant
JAM-A/F11R/CD321	Human	JAM-A/F11R Protein, Recombinant
JAM-A/F11R/CD321	Mouse	JAM-A/F11R/Fc Protein, Recombinant
JAM-B/JAM2/VE-JAM	Mouse	JAM-B/JAM2/VE-JAM/Fc Protein, Recombinant
JAM-B/JAM2/VE-JAM	Mouse	JAM-B/JAM2/VE-JAM Protein, Recombinant
JAM-C/JAM3	Mouse	JAM-C/JAM3 Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human JAM-A/F11R/CD321	ELISA	Mouse Monoclonal Antibody
Human JAM-A/F11R/CD321	WB	Mouse Monoclonal Antibody
Human JAM-A/F11R/CD321	ELISA	Rabbit Polyclonal Antibody
Human JAM-A/F11R/CD321	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
JAM-A/F11R/CD321	Human	Homo sapiens JAM-A/F11R cDNA Clone(NM_016946.4)
JAM-A/F11R/CD321	Mouse	Mus musculus JAM-A/F11R cDNA Clone
JAM-B/JAM2/VE-JAM	Human	Homo sapiens JAM-B/JAM2/VE-JAM cDNA Clone
JAM-B/JAM2/VE-JAM	Mouse	Mus musculus JAM-B/JAM2/VE-JAM cDNA Clone
JAM-C/JAM3	Mouse	Mus musculus JAM-C/JAM3 cDNA Clone

JAML Background

Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), a protein related to the JAM family, is restricted to leukocytes and promotes their adhesion to endothelial cells. It contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail involved in activation signaling. Monocytic JAML plays a critical role in regulating monocyte transendothelial migration (TEM) probably via binding to the endothelial coxsackie and adenovirus receptor (CAR) and other tight junction-associated adhesive molecules. The Expression of JAML is restricted to the hematopoietic tissues with the exception of liver. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML also enhances myeloid leukemia cell adhesion to endothelial cells.

JAML Related Studies

1. Moog-Lutz C, et al. (2003) JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood. 102(9): 3371-8.
2. Luissint AC, et al. (2008) JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. J Cell Biol. 183(6): 1159-73.
3. Guo YL, et al. (2009) Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. Arterioscler Thromb Vasc Biol. 29(1): 75-83.