Anti-JAML Antibody

Cat: 10120-RP02
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All JAML Reagents
CRO Services
Product recommended

All JAML Reagents
Anti-JAML Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-JAML Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human JAML
Immunogen
Recombinant Human JAML protein (Catalog#10120-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human JAML (rh JAML; Catalog#10120-H08H; NP_001091996.1; Met 1-Leu 275). JAML specific IgG was purified by human JAML affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-JAML Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-JAML Antibody Alternative Names
Anti-AMICA Antibody;Anti-CREA7-1 Antibody;Anti-CREA7-4 Antibody;Anti-Gm638 Antibody;Anti-JAML Antibody
JAML Background Information

Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), a protein related to the JAM family, is restricted to leukocytes and promotes their adhesion to endothelial cells. It contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail involved in activation signaling. Monocytic JAML/AMICA1 plays a critical role in regulating monocyte transendothelial migration (TEM) probably via binding to the endothelial coxsackie and adenovirus receptor (CAR) and other tight junction-associated adhesive molecules. The Expression of JAML/AMICA1 is restricted to the hematopoietic tissues with the exception of liver. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML/AMICA1 also enhances myeloid leukemia cell adhesion to endothelial cells.

Full Name
adhesion molecule, interacts with CXADR antigen 1
References
  • Moog-Lutz C, et al. (2003) JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood. 102(9): 3371-8.
  • Luissint AC, et al. (2008) JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. J Cell Biol. 183(6): 1159-73.
  • Guo YL, et al. (2009) Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. Arterioscler Thromb Vasc Biol. 29(1): 75-83.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-JAML Antibody Rabbit Polyclonal ELISA 10120-RP01
    Anti-JAML Antibody Mouse Monoclonal ELISA(Det) 10120-MM06
    Anti-JAML Antibody Mouse Monoclonal ELISA(Cap) 10120-MM05
    Anti-JAML Antibody Mouse Monoclonal ELISA 10120-MM08
    info info
    添加购物车成功! 添加购物车失败!