Junctional Adhesion Molecule A Protein & Antibody (JAM-A)

Junctional Adhesion Molecule A Alternative Names

F11R, CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1 [Homo sapiens]

F11r, JAM, JAM-1, JAM-A, Jcam, Jcam1, Ly106, 9130004G24, AA638916, ESTM33 [Mus musculus]

Junctional Adhesion Molecule A Products

Junctional Adhesion Molecule A Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
JAM-A/F11R/CD321	Human	JAM-A/F11R/Fc Protein, Recombinant	10198-H02H
JAM-A/F11R/CD321	Human	JAM-A/F11R Protein, Recombinant	10198-H08H
JAM-A/F11R/CD321	Mouse	JAM-A/F11R/Fc Protein, Recombinant	50463-M02H

  10198-H02H: When 8 x 10⁴ cells/well are added to JAMA coated plates (0.2 µg/mL and 100 µL/well), approximately 30-40% will adhere specifically after 60 minutes at 37℃.Measured by its ability of the immobilized protein to support the adhesion of Jurkat human leukemic T cells.

  10198-H08H: When 8 x 10⁴ cells/well are added to JAMA coated plates (0.2 µg/mL and 100 µL/well), approximately 40-65% will adhere specifically after 60 minutes at 37℃.Measured by its ability of the immobilized protein to support the adhesion of Jurkat human leukemic T cells.

Junctional Adhesion Molecule A Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human JAM-A/F11R/CD321	ELISA	Mouse Monoclonal Antibody	10198-MM02
Human JAM-A/F11R/CD321	WB	Mouse Monoclonal Antibody	10198-MM03
Human JAM-A/F11R/CD321	ELISA	Rabbit Polyclonal Antibody	10198-RP01
Human JAM-A/F11R/CD321	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10198-RP04

Junctional Adhesion Molecule A ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human JAM-A/F11R/CD321	ELISA	JAM-A/F11R/CD321 ELISA Kit	SEK10198

Junctional Adhesion Molecule A Related Areas

Cardiovascular>>Platelet>>JAM-A/F11R/CD321

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>JAM-A/F11R/CD321

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM) >>JAM-A/F11R/CD321

Immunology>>Cluster of Differentiation>>Other>>JAM-A/F11R/CD321

Junctional Adhesion Molecule A Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
JAM-B/JAM2/VE-JAM	Mouse	JAM-B/JAM2/VE-JAM/Fc Protein, Recombinant
JAM-B/JAM2/VE-JAM	Mouse	JAM-B/JAM2/VE-JAM Protein, Recombinant
JAM-C/JAM3	Mouse	JAM-C/JAM3 Protein, Recombinant
JAML/AMICA	Human	JAML/AMICA Protein, Recombinant
ESAM	Human	ESAM/Fc Protein, Recombinant
ESAM	Human	ESAM Protein, Recombinant
ESAM	Human	ESAM Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human ESAM	WB, ELISA	ESAM Antibody, Mouse MAb
Human ESAM	WB, ELISA	Rabbit Polyclonal Antibody
Human ESAM	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human JAML/AMICA1	WB, ELISA	JAML/AMICA1 Antibody, Rabbit PAb
Human JAML/AMICA1	WB, ELISA	JAML/AMICA1 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
JAM-B/JAM2/VE-JAM	Human	Homo sapiens JAM-B/JAM2/VE-JAM cDNA Clone
JAM-B/JAM2/VE-JAM	Mouse	Mus musculus JAM-B/JAM2/VE-JAM cDNA Clone
JAM-C/JAM3	Mouse	Mus musculus JAM-C/JAM3 cDNA Clone
JAML/AMICA	Human	Homo sapiens JAML/AMICA  transcript variant 1 cDNA Clone(NM_001098526.1)
ESAM	Human	Homo sapiens ESAM cDNA Clone(NM_138961.2)

Junctional Adhesion Molecule A Background

Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.

Junctional Adhesion Molecule A Related Studies

1. Guglielmi KM, et al. (2007) Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem. 282(24): 17930-40.
2. Yeung D, et al. (2008) Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown. Acta Neuropathol. 115(6): 635-42.
3. Ong KL, et al. (2009) Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension. Am J Hypertens. 22(5): 500-5.