Junctional Adhesion Molecule C Protein & Antibody (JAM-C, JAM3 Protein)

Junctional Adhesion Molecule C Products

Junctional Adhesion Molecule C Protein, Recombinant

Molecule	Species	Description	Cat. No
JAM-C/JAM3	Mouse	JAM-C / JAM3 Protein, Recombinant	50465-M08H
JAM-C/JAM3	Human	JAM3 / JAM-C Protein, Recombinant	13152-H02H

Junctional Adhesion Molecule C Antibody

Molecule	Application	Description	Cat. No
Mouse JAM-C/JAM3	WB, ELISA	JAM-3 / JAM-C Antibody (Antigen Affinity Purified)	50465-RP02

Junctional Adhesion Molecule C cDNA Clone

Molecule	Species	Description	Cat. No
JAM-C/JAM3	Mouse	Mus musculus JAM-C / JAM3 cDNA Clone	MG50465-M
JAM-C/JAM3	Human	JAM3 cDNA Clone / ORF Clone	HG13152-G

Junctional Adhesion Molecule C Related Areas

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>JAM-C/JAM3

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>JAM-C/JAM3

Junctional Adhesion Molecule C Alternative Names

JAM-C, JAM3, JAM-3, JAM-2, UNQ859/PRO1868, FLJ14529, JAMC [Homo sapiens]

JAM-C, Jam3, JAM-3, JAM-2, 1110002N23Rik, C85515, Jcam3 [Mus musculus]

Junctional Adhesion Molecule C Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
JAM-A/F11R/CD321	Human	JAM-A/F11R/Fc Protein, Recombinant
JAM-A/F11R/CD321	Human	JAM-A/F11R Protein, Recombinant
JAM-A/F11R/CD321	Mouse	JAM-A/F11R/Fc Protein, Recombinant
JAM-B/JAM2/VE-JAM	Mouse	JAM-B/JAM2/VE-JAM/Fc Protein, Recombinant
JAM-B/JAM2/VE-JAM	Mouse	JAM-B/JAM2/VE-JAM Protein, Recombinant
JAML/AMICA1	Human	JAML/AMICA1 Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human JAM-A/F11R/CD321	ELISA	Mouse Monoclonal Antibody
Human JAM-A/F11R/CD321	WB	Mouse Monoclonal Antibody
Human JAM-A/F11R/CD321	ELISA	Rabbit Polyclonal Antibody
Human JAM-A/F11R/CD321	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human JAML/AMICA1	WB, ELISA	JAML/AMICA1 Antibody, Rabbit PAb
Human JAML/AMICA1	WB, ELISA	JAML/AMICA1 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
JAM-A/F11R/CD321	Human	Homo sapiens JAM-A/F11R cDNA Clone(NM_016946.4)
JAM-A/F11R/CD321	Mouse	Mus musculus JAM-A/F11R cDNA Clone
JAM-B/JAM2/VE-JAM	Human	Homo sapiens JAM-B/JAM2/VE-JAM cDNA Clone
JAM-B/JAM2/VE-JAM	Mouse	Mus musculus JAM-B/JAM2/VE-JAM cDNA Clone
JAML/AMICA1	Human	Homo sapiens JAML/AMICA1 transcript variant 1 DNA ORF Clone(NM_001098526.1)

Junctional Adhesion Molecule C Background

Junctional adhesion molecule C, also known as Junctional adhesion molecule 3, JAM3, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. It is an adhesion molecule expressed by endothelial cells (ECs) that plays a role in tight junction formation, leukocyte adhesion, and transendothelial migration. JAM-C is an adhesion molecule that is expressed on cells within the vascular compartment and epithelial cells and, to date, has been largely studied in the context of inflammatory events. JAM-C is also expressed in peripheral nerves and that this expression is localized to Schwann cells at junctions between adjoining myelin end loops. JAM-C is a component of the autotypic junctional attachments of Schwann cells and plays an important role in maintaining the integrity and function of myelinated peripheral nerves. JAM-C was recently shown to be a counter receptor for the leukocyte beta2-integrin Mac-1 (CD11b/CD18), thereby mediating interactions between vascular cells, particularly in inflammatory cell recruitment. JAM-C is up-regulated by oxidized low-density lipoprotein (LDL) and may thereby contribute to increased inflammatory cell recruitment during atherosclerosis. JAM-C may therefore provide a novel molecular target for antagonizing interactions between vascular cells in atherosclerosis. JAM-C was shown to undergo a heterophilic interaction with the leukocyte beta2 integrin Mac-1, thereby mediating interactions between vascular cells in inflammatory cell recruitment. JAM-C undergoes a homophilic interaction via the Arg64-Ile65-Glu66 motif on the membrane-distal Ig domain of the molecule. The homophilic interaction of JAM-C can mediate tumor cell-endothelial cell interactions and may thereby be involved in the process of tumor cell metastasis.

Junctional Adhesion Molecule C Related Studies

1. Keiper T, et al. (2005) The role of junctional adhesion molecule-C (JAM-C) in oxidized LDL-mediated leukocyte recruitment. FASEB J. 19(14): 2078-80.
2. Santoso S, et al. (2005) The homophilic binding of junctional adhesion molecule-C mediates tumor cell-endothelial cell interactions. J Biol Chem. 280(43): 36326-33.
3. Scheiermann C, et al. (2007) Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves. Science. 318(5855): 1472-5.
4. Mandicourt G, et al. (2007) JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration. J Biol Chem. 282(3): 1830-7.
5. Betanzos A, et al. (2009) Evidence for cross-reactivity of JAM-C antibodies: implications for cellular localization studies. Biol Cell. 101(8): 441-53.
6. Rabquer BJ, et al. (2010) Junctional adhesion molecule-C is a soluble mediator of angiogenesis. J Immunol. 185(3): 1777-85.