Junctional Adhesion Molecule B Protein & Antibody (JAM-B,JAM-2 Protein)

Junctional Adhesion Molecule B Products

Junctional Adhesion Molecule B Protein, Recombinant

Molecule	Species	Description	Cat. No
JAM-B/JAM2/VE-JAM	Mouse	JAM-B/JAM2/VE-JAM/Fc Protein, Recombinant	50464-M02H
JAM-B/JAM2/VE-JAM	Mouse	JAM-B/JAM2/VE-JAM Protein, Recombinant	50464-M08H

  50464-M02H: When 8 x 10⁴ cells/well are added to JAM2 coated plates (0.2 µg/mL and 100 µL/well), approximately 40-55% will adhere specifically after 60 minutes at 37℃.Measured by its ability of the immobilized protein to support the adhesion of Jurkat human leukemic T cells.

  50464-M08H: When 8 x 10⁴ cells/well are added to JAM2 coated plates (0.2 µg/mL and 100 µL/well), approximately 35-60% will adhere specifically after 60 minutes at 37℃.Measured by its ability of the immobilized protein to support the adhesion of Jurkat human leukemic T cells.

Junctional Adhesion Molecule B Antibody

Molecule	Application	Description	Cat. No
Mouse JAM-B/JAM2/VE-JAM	WB, ELISA	JAM-2 / JAM-B Antibody	50464-RP01
Mouse JAM-B/JAM2/VE-JAM	WB, ELISA	JAM-2 / JAM-B Antibody (Antigen Affinity Purified)	50464-RP02

Junctional Adhesion Molecule B cDNA Clone

Molecule	Species	Description	Cat. No
JAM-B/JAM2/VE-JAM	Human	Homo sapiens JAM-B/JAM2/VE-JAM cDNA Clone	HG10580-M
JAM-B/JAM2/VE-JAM	Mouse	Mus musculus JAM-B/JAM2/VE-JAM cDNA Clone	MG50464-M
JAM-B/JAM2/VE-JAM	Rat	JAM2 cDNA Clone / ORF Clone	RG80376-G

Junctional Adhesion Molecule B Related Areas

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>JAM-B/JAM2/VE-JAM/CD322

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>JAM-B/JAM2/VE-JAM/CD322

Immunology>>Cluster of Differentiation>>JAM-B/JAM2/VE-JAM/CD322

Junctional Adhesion Molecule B Alternative Names

JAM-B, JAMB, JAM2, VE-JAM, VEJAM, JAM-2, JAM-IT/VE-JAM, UNQ219/PRO245, C21orf43, CD322, PRO245 [Homo sapiens]

JAM-B, JAM-2, VE-JAM, RP23-253E17.2, 1110002N23Rik, 2410030G21Rik, 2410167M24Rik, AU016127, Jcam2 [Mus musculus]

Junctional Adhesion Molecule B Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
JAM-A/F11R/CD321	Human	JAM-A/F11R/Fc Protein, Recombinant
JAM-A/F11R/CD321	Human	JAM-A/F11R Protein, Recombinant
JAM-A/F11R/CD321	Mouse	JAM-A/F11R/Fc Protein, Recombinant
JAM-C/JAM3	Mouse	JAM-C/JAM3 Protein, Recombinant
JAML/AMICA1	Human	JAML/AMICA1 Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human JAM-A/F11R/CD321	ELISA	Mouse Monoclonal Antibody
Human JAM-A/F11R/CD321	WB	Mouse Monoclonal Antibody
Human JAM-A/F11R/CD321	ELISA	Rabbit Polyclonal Antibody
Human JAM-A/F11R/CD321	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human JAML/AMICA1	WB, ELISA	JAML/AMICA1 Antibody, Rabbit PAb
Human JAML/AMICA1	WB, ELISA	JAML/AMICA1 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
JAM-A/F11R/CD321	Human	Homo sapiens JAM-A/F11R cDNA Clone(NM_016946.4)
JAM-A/F11R/CD321	Mouse	Mus musculus JAM-A/F11R cDNA Clone
JAM-C/JAM3	Mouse	Mus musculus JAM-C/JAM3 cDNA Clone
JAML/AMICA1	Human	Homo sapiens JAML/AMICA1 transcript variant 1 DNA ORF Clone(NM_001098526.1)

Junctional Adhesion Molecule B Background

Junctional adhesion molecule B (JAM-B), also known as Junctional adhesion molecule 2 (JAM2), Vascular endothelial junction-associated molecule (VE-JAM), and CD322, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. It is prominently expressed on high endothelial venules. expression to be restricted to the high endothelial venule of tonsil and lymph nodes. The localization to the endothelium of arterioles in and around inflammatory and tumor foci. JAM-B can function as an adhesive ligand for the T cell line J45 and can interact with GM-CSF/IL-4-derived peripheral blood dendritic cells, circulating CD56(+) NK cells, circulating CD56(+)CD3(+) NK/T cells, and circulating CD56(+)CD3(+)CD8(+) cytolytic T cells. JAM-2 is expressed on high endothelial venules (HEVs) in human tonsil and on a subset of human leukocytes, suggesting that JAM-2 plays a central role in the regulation of transendothelial migration. It binds to very late activation antigen (VLA)-4, a leucocyte integrin that contributes to rolling and firm adhesion of lymphocytes to endothelial cells through binding to vascular cell adhesion molecule (VCAM)-1. JAM-B appears to contribute to leucocyte extravasation by facilitating not only transmigration but also rolling and adhesion. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

Junctional Adhesion Molecule B Related Studies

1. Johnson-Léger CA, et al. (2002) Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. Blood. 2100(7): 2479-86.
2. Liang TW, et al. (2002) Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3. J Immunol. 168(4): 1618-26.
3. Ludwig RJ, et al. (2009) Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin. Immunology. 128(2): 196-205.