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JAM-A / F11R Antibody (PE), Mouse MAb

  • JAM-A / F11R Antibody (PE), Mouse MAb, Flow cytometric
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Human JAM-A/JAM1/F11R Antibody Product Information
Immunogen:Recombinant Human JAM-A / F11R / CD321 protein (Catalog#10198-H08H)
Clone ID:04
Ig Type:Mouse IgG1
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human JAM-A / F11R / CD321 (rh JAM-A / F11R / CD321; Catalog#10198-H08H; NP_058642.1; Met 1-Ala 242) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Human JAM-A/JAM1/F11R Antibody FC Application Image
JAM-A / F11R Antibody (PE), Mouse MAb, Flow cytometric
[Click to enlarge image]
Caption:
Profile of anti-JAM-A (CD321) reactivity on SKBR3 cells analyzed by flow cytometry.
Other JAM-A/JAM1/F11R Antibody Products
Junctional Adhesion Molecule A Background

Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.

Human Junctional Adhesion Molecule A References
  • Guglielmi KM, et al. (2007) Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem. 282(24): 17930-40.
  • Yeung D, et al. (2008) Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown. Acta Neuropathol. 115(6): 635-42.
  • Ong KL, et al. (2009) Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension. Am J Hypertens. 22(5): 500-5.
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    Catalog: 10198-MM04-P-100
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    100 Tests
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"