Anti-JAM-A Antibody

Cat: 10198-R005
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Anti-JAM-A Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-JAM-A Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human JAM-A
Immunogen
Recombinant Human JAM-A protein (Catalog#10198-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human JAM-A extracellular domain (rh JAM-A; Catalog#10198-H08H; Met 1-Ala 242; NP_058642.1).
Source
Monoclonal Rabbit IgG Clone #5
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-JAM-A Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.1-0.2 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-JAM-A Antibody Alternative Names
Anti-CD321 Antibody;Anti-JAM Antibody;Anti-JAM1 Antibody;Anti-JAMA Antibody;Anti-JCAM Antibody;Anti-KAT Antibody;Anti-PAM-1 Antibody
JAM-A Background Information

Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.

Full Name
F11 receptor
References
  • Guglielmi KM, et al. (2007) Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem. 282(24): 17930-40.
  • Yeung D, et al. (2008) Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown. Acta Neuropathol. 115(6): 635-42.
  • Ong KL, et al. (2009) Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension. Am J Hypertens. 22(5): 500-5.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-JAM-A Antibody (PE) Mouse Monoclonal FCM 10198-MM04-P
    Anti-JAM-A Antibody Rabbit Polyclonal ELISA 10198-T16
    Anti-JAM-A Antibody (APC) Mouse Monoclonal FCM 10198-MM04-A
    Anti-JAM-A Antibody Rabbit Polyclonal WB,ELISA,IP 10198-RP04
    Anti-JAM-A Antibody (FITC) Mouse Monoclonal FCM 10198-MM04-F
    Anti-JAM-A Antibody Mouse Monoclonal ELISA,ELISA(Det) 10198-MM02
    Anti-JAM-A Antibody Mouse Monoclonal FCM,ICC/IF,IF 10198-MM04
    Anti-JAM-A Antibody Rabbit Polyclonal ELISA 10198-RP01
    Anti-JAM-A Antibody Mouse Monoclonal ELISA(Cap) 10198-MM08
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