Anti-Jagged 1 Antibody (FITC)

Cat: 11648-MM03-F
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Anti-Jagged 1 Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-Jagged 1 Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human Jagged 1
Immunogen
Recombinant Human JAG1 / Jagged 1 protein (Catalog#11648-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human JAG1 / Jagged 1 (rh JAG1 / Jagged 1; Catalog#11648-H08H; NP_000205.1; Met1-Ser1046) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG2a Clone #03
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-Jagged 1 Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Jagged 1 Antibody (FITC) (Mouse Monoclonal antibody) Images
Human Jagged 1/JAG1/CD339 Flow Cytometry (FC) 2572
Profile of anti-JAG1(CD339) reactivity on HepG2 cells analyzed by flow cytometry.
Anti-Jagged 1 Antibody (FITC) Alternative Names
Anti-AGS Antibody;Anti-AHD Antibody;Anti-AWS Antibody;Anti-CD339 Antibody;Anti-HJ1 Antibody;Anti-Jagged 1 Antibody;Anti-JAGL1 Antibody
Jagged 1 Background Information

Protein Jagged 1, also known as JAG1, JAGL1 and CD339, is a single-pass type I  membrane protein which contains 1 DSL domain and 15 EGF-like domains. JAG1/Jagged 1 is widely expressed in adult and fetal tissues. The expression of JAG1/Jagged 1 is up-regulated in cervical squamous cell carcinoma. JAG1/Jagged 1 is also expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. JAG1/Jagged 1 is a ligand for multiple Notch receptors. It is involved in the mediation of Notch signaling. JAG1/Jagged 1 may be involved in cell-fate decisions during hematopoiesis. 

JAG1/Jagged 1 seems to be involved in early and late stages of mammalian cardiovascular development. It inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1/Jagged 1 are the cause of Alagille syndrome type 1 (ALGS1). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. Defects in JAG1/Jagged 1 are also a cause of tetralogy of Fallot (TOF). TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation.

Full Name
jagged 1
References
  • Oda T.et al., 1997, Nat. Genet. 16:235-242.
  • Krantz I.D. et al., 1998, Am. J. Hum. Genet. 62:1361-1369.
  • Li L. et al., 1998, Immunity. 8:43-55.
  • Jones E.A. et al., 2000, J. Med. Genet. 37: 658-662.
  • Roepke A.et al., 2003, Hum. Mutat. 21:100-100.
  • Jurkiewicz D.et al., 2005, Hum. Mutat. 25:321-321.
  • Warthen D.M.et al., 2006, Hum. Mutat. 27:436-443.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Jagged 1 Antibody (PE) Mouse Monoclonal FCM 11648-MM03-P
    info info
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