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- Cytokine Signaling
>Interleukin / Interleukins
Interleukin / Interleukins
Interleukins are a group of cytokines that were first seen to be expressed by leukocytes. The term interleukin describes a variety of polypeptides that act specifically as mediators between leucocytes. More about What are Interleukins.
The Interleukin-1 superfamily & Interleukin-1 receptor family plays critical roles in initiating and promoting the host response to injury or infection, including... More about IL-1 / Interleukin 1 & Receptor.
Interleukin 2, a factor secreted by lectin- or antigen-stimulated T-cells, is a lymphokine that induces the proliferation of responsive T-cells. In addition... More about IL-2 / Interleukin 2 & Receptor.
Members of the interleukin-6 family cytokines utilize one or both of the shared receptor signal transducing subunits, gp130 and LIF receptor (LIFR). Interleukin-6 family cytokines binding of gp130 activates the JAK/STAT signaling pathway, More about IL-6 / Interleukin 6 & Receptor.
Interleukin-10, also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 shares use of IL-10 receptor 2 (IL-10R2) in cell signaling with other members of this family (L-22, IL-26) and interferon-like molecules (limitin, L-28A, IL-28B, IL-29). More about IL-10 / Interleukin 10 & Receptor .
The interleukin-12 family cytokines are key players in the regulation of T cell responses. Interleukin-12 has long been appreciated to play central role in the generation of TH1 cells. More about IL-12 / Interleukin 12 & Receptor.
Cytokines of the interleukin-17 family include IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (or IL-25), and IL-17F. Interleukin-17 family members have been reported to function in numerous immune processes. Most notably, IL-17 is involved in inducing and mediating proinflammatory responses. More about IL-17 / Interleukin 17 & Receptor.
Interleukin Related Studies
- Arkin, M.A, et al. (2003) Binding of small molecules to an adaptive protein-protein interface. Proc.Natl.Acad.Sci.USA 100: 1603-1608.
- Gibeon D, et al. (2012) Targeting interleukins to treat severe asthma. Expert Rev Respir Med. 6(4):423-39.
- Thomas A, et al. (2006) The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nature Reviews Immunology 6, 595-601.
- Giorgio T, et al. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nature Reviews Immunology 3, 133-146.
- Stuart M, et al. (2005) Interleukin-1 and neuronal injury. Nature Reviews Immunology 5, 629-640.
- C. M. Hawrylowicz, et al. (2005) Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nature Reviews Immunology 5, 271-283.
- Stanislas G, et al. (2008) How microorganisms tip the balance between interleukin-12 family members. Nature Reviews Immunology 8, 81-86.
- Brocker C, et al. (2010) Evolutionary divergence and functions of the human interleukin (IL) gene family. Human Genomics 5 (1): 30–55.
- Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J. Biol. Chem. 271 (34): 20965–72.
- McMahan CJ, et al. (1991) A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 10 (10): 2821–32.
- Presky DH, et al. (1998) The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16: 495–521.
- Jiang H, et al. (1995) Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 11 (12): 2477–2486.
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