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>Human Cell Expressed
>Rat Interleukin 25 / IL25 / IL17E Protein
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Interleukin 25 Protein Datasheet
Interleukin 25 / IL25 / IL17E Protein Price Inquiry ( Available Sizes )
Interleukin 25 / IL25 / IL17E Protein Product Information
A DNA sequence encoding the rat IL25 (D3ZLB1)(Val17-Ala169) was expressed, fused with Fc region of human IgG1 at the N-terminus.
|Expression Host:||Human Cells|
Interleukin 25 / IL25 / IL17E Protein QC Testing
|Purity:||> 85 % as determined by SDS-PAGE||SDS-PAGE:
Interleukin 25 / IL25 / IL17E protein
|Measured by its binding ability in a functional ELISA.
Immobilized mouse IL17BR-His (Cat:51109-M08H) at 10 μg/mL (100 μl/well) can bind rat Fc-IL25 (Cat:80194-R01H). The EC50 of rat Fc-IL25 is 0.12-0.27 μg/mL.
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Glu|
The recombinant rat IL25 comprises 413 amino acids and predicts a molecular mass of 46.1 kDa. The apparent molecular mass of the recombinant protein is approximately 49 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
Interleukin 25 / IL25 / IL17E Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
Interleukin 25 / IL25 / IL17E Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|IL-25/IL-17E||Human||IL-25/IL-17E/Fc Protein, Recombinant||10096-H01H|
|IL-25/IL-17E||Mouse||IL-25/IL-17E Protein, Recombinant||50138-M07H|
|IL-25/IL-17E||Rat||Interleukin 25 / IL25 / IL17E Protein, Recombinant||80194-R01H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||Rabbit Polyclonal Antibody||50138-RP01|
|WB, ELISA||Rabbit Polyclonal Antibody (Antigen Affinity Purified)||50138-RP02|
Interleukin 25 / IL25 / IL17E Protein Description
Interleukin 25 (IL-25), also known as IL17E, is a cytokine that belongs to the IL17 cytokine family and is secreted by type 2 helper T cells (Th2) and mast cells. IL-25 induces the production of other cytokines, including IL-4, IL-5 and IL-13 in multiple tissues, then induces Th2 immune responses such as blood eosinophilia and increased serum immunoglobulin E levels.This cytokine is an important molecule controlling immunity of the gut and has been implicated in chronic inflammation associated with the gastrointestinal tract. Further, the IL-25 gene has been identified in a chromosomal region associated with autoimmune diseases of the gut such as inflammatory bowel disease (IBD). In addition, studies shown that enforced expression of IL-25 in the lung significantly enhances antigen-induced Th2 cytokine production and eosinophil recruitment into the airways, thus suggesting an important role of IL-25in enhancing allergic airway inflammation by a CD4+ T-cell-dependent mechanism.
- Kei I. et al., 2003, Blood. 101: 3594-6.
- Buning. et al., 2003, European Journal of Immunogenetics. 30: 329-33.
- Owyang. et al., 2006, Journal of Experimental Medicine. 203: 843-9.
- Tamachi T. et al., 2006, Int Arch Allergy Immunol. 1: 59-62.
- Angkasekwinai P. et al., 2007, J Exp Med. 204: 1509-17.
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