IL-17 Family & IL-17 Receptor Family Protein & Antibody

IL-17 Family & IL-17 Receptor Family Protein & Antibody Products Index

IL-17 Family Ligand Protein & Antibody

• IL-17A
• IL-17D
• IL-25 / IL-17E
• IL-17C
• IL-17F

IL-17 Family Receptor Protein & Antibody

• IL-17R / IL-17RA / CD217
• IL-17RB / IL-17BR
• IL-17RD
• IL-17RC

IL-17 Family & IL-17 Receptor Family Background

Cytokines of the IL-17 family include IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. All members of the IL-17 family have a similar protein structure, with four highly conserved cysteine residues critical to their 3-dimensional shape. Cytokines of IL-17 family are all well conserved in mammals, with as much as 62–88% of amino acids conserved between the human and mouse homologs.

IL-17 family of cytokines have been reported to function in numerous immune processes. Most notably, IL-17 is involved in inducing and mediating proinflammatory responses. This proinflammatory activity is exemplified by their involvement in pulmonary inflammatory responses. Both IL-17A and IL-17F are involved in the recruitment of neutrophils, and IL-17E is able to induce Th2 cytokine production and eosinophilia.

The IL-17 receptor family consists of five members, IL-17RA, IL-17RB, IL-17RC, IL-17RD and IL-17RE. Functional IL-17R is a heteromeric complex consisting of at least IL17RA and IL17RC. IL-17 receptors are broadly distributed, with individual ligand specificities. IL-17R binds both IL-17A and IL-17F and is expressed in multiple tissues. L-17RB, binds both IL-17B and IL-17E.

IL-17 Family & IL-17 Receptor Family Related Studies

1. Kawaguchi M, et al. (2004) IL-17 cytokine family. J Allergy Clin Immunol. 114(6):1265-73.
2. Gaffen SL, et al. (2006) The IL-17 cytokine family. Vitam Horm. 74:255-82.
3. Wang YH, et al. (2008) The IL-17 cytokine family and their role in allergic inflammation. Curr Opin Immunol. 20(6):697-702.
4. Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9(8):556-67.
5. Johansen C, et al. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160(2):319-24.