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Human Interferon beta / IFN-beta / IFNB Protein
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Human Interferon beta / IFN-beta / IFNB Protein (Cytokine) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
10704-HNAS  

YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Interferon, beta 1, fibroblast Protein Datasheet

 

Interferon beta / IFN-beta / IFNB Protein Price Inquiry ( Available Sizes )

Interferon beta / IFN-beta / IFNB Protein Product Information

Synonym : IFNβ, IFNB1, IFB, IFNB
Protein Construction:

A DNA sequence encoding the human IFNβ (P01574) (Met1-Asn187) was expressed.

Source: Human
Expression Host: CHO Stable Cells

Interferon beta / IFN-beta / IFNB Protein QC Testing

Purity: > 95 % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

Interferon beta / IFN-beta / IFNB protein

Bio-activity:

Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitisvirus (VSV).
The EC50 for this effect is 1-5 pg/mL.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Met 22
Molecular Mass:

The recombinant human IFNβ  consists of  166 amino acids and predicts a molecular mass of 20 KDa. It migrates as an approximately 20-23 KDa band in SDS-PAGE under reducing conditions.

Formulation: Lyophilized from sterile 50mM Hepes, PH 7.0.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

Interferon beta / IFN-beta / IFNB Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Interferon beta / IFN-beta / IFNB Protein Related Products & Topics

Related Areas:

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IFN beta/IFNB

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-10/Interferon Family>>IFN beta/IFNB

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
IFN beta/IFNB Human IFN beta/IFNB/Fc Protein, Recombinant 10704-H02H
IFN beta/IFNB Human IFN beta/IFNB Protein, Recombinant 10704-HNAC
IFN beta/IFNB Mouse IFNB1 / IFN-beta / Interferon beta Protein, Recombinant 50708-M02H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
IFN beta/IFNB
WB, ELISA Mouse Monoclonal Antibody 10704-MM01
Human
IFN beta/IFNB
WB, ELISA IFN beta Antibody (Antigen Affinity Purified) 10704-RP02

Interferon beta / IFN-beta / IFNB Protein Description

Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites and tumor cells. IFNs are produced by a wide variety of cells in response to the presence of dsRNA, a key indicator of viral infection via a pattern recognition receptor of the innate immune system Toll Like Receptor 3 (TLR 3), and in turn assists the immune response by inhibiting viral replication within host cells, activating natural killer cells and macrophages, increasing antigen presentation to lymphocytes, and inducing the resistance of host cells to viral infection. There are three major classes of IFNs according to the receptor type through which they signal, and the type I IFNs bind to a specific receptor complex known as the IFN-α receptor (IFNAR) consisting of IFNAR1 and IFNAR2 chains. The type I  IFNs present in humans are IFN-α, IFN-β and IFN-ω and IFN-β is produced by fibroblast. In addition to the common antiviral activity, IFN-β also induces increased production of the p53 gene product which promotes apoptosis, and thus has therapeutic effect against certain cancers. Furthermore, IFN-β might play a beneficial role in the development of a chronic progressive CNS inflammation.

References

  1. Morikawa K. et al., 1987, J Immunol. 139: 761-6.
  2. Sato K. et al., 2001, Eur J Immunol. 31: 3188-46.
  3. Takaoka A. et al., 2003, Nature. 424: 516-23.
  4. Improta T. et al., 1997, Cytokine. 9: 383-93.
  5. Teige I. et al., 2006, J Immunol. 177: 3542-53.
 

All Interferon Proteins

Product name Product name
IFNα4 / IFNa4 / Interferon alpha-4 Protein Rat IFNG / Interferon Gamma Protein
IFNαG / IFNaG / Interferon alpha-G Protein Rat IFN-alpha / IFNA1 / IFN Protein (His Tag)
Interferon beta / IFN-beta / IFNB Protein IFNA5 / IFNaG Protein (His Tag)
IFNγR1 / CD119 Protein Rat IFNA4 / IFNα4 / Interferon alpha-4 Protein
Interferon omega-1 / IFNω / IFNW1 Protein IFNW1 Protein (His Tag)
IFN-gamma R1 Protein (His Tag) Rat IFNA5 / IFNaG Protein (His Tag)
Mouse IFNAR1 / IFNAR Protein (His Tag) Interferon beta / IFN-beta / IFNB Protein (Native)
IFNAR2 / IFNABR Protein Cynomolgus IFNA4 / IFNα4 / Interferon alpha-4 Protein
IFNAR2 / IFNABR Protein (His Tag) Cynomolgus IFNA2 / Interferon alpha 2 Protein
IFN-gamma / IFNG / γ-IFN Protein (Native) Cynomolgus IFNA13 / Interferon alpha-13 Protein
Interferon beta / IFN-beta / IFNB Protein (Native) Rat IFNGR / IFNGR1 Protein
IL28B / IL28C / Interleukin-28B Protein (His Tag) Cynomolgus IFNA13 / Interferon alpha-13 Protein (His Tag)
IL-29 / Interleukin-29 Protein (His Tag) Cynomolgus IFNGR / IFNGR1 Protein
Mouse IFNGR2 Protein (His Tag) Cynomolgus IFNAR1 / IFNAR Protein (His Tag)
Mouse IFNG / Interferon Gamma Protein Mouse IFNB1 / IFN-beta / Interferon beta Protein
Mouse IFNG / Interferon Gamma Protein (His Tag) Cynomolgus Interferon alpha-B / IFNA8 Protein
Mouse IFNA14 / Interferon alpha-14 Protein Cynomolgus Interferon alpha-B / IFNA8 Protein (His Tag)
Mouse IFNA4 / Interferon alpha-4 Protein Interferon alpha-B / IFNA8 Protein
Mouse IFNA13 / Interferon alpha-13 Protein Ferret IFNG / Interferon Gamma Protein (His Tag)
Mouse IFNGR1 / CD119 Protein Cynomolgus IFNGR / IFNGR1 Protein (His Tag)
Mouse IFNGR1 / CD119 Protein (His Tag) Cynomolgus IFNA2 / Interferon alpha 2 Protein (His Tag)
Mouse IFNB1 / IFN-beta / Interferon beta Protein Mouse IFNA14 / Interferon alpha-14 Protein (His Tag)
Interferon alpha 7 / IFNA7 Protein Cynomolgus IFNB1 / IFN-beta / Interferon beta Protein
Interferon alpha 10 / IFNA10 Protein Cynomolgus IFNAR1 / IFNAR Protein
IFNα4 / IFNa4 / Interferon alpha-4 Protein (His Tag) Mouse IFNA13 / Interferon alpha-13 Protein (His Tag)
IFNAR1 / IFNAR Protein Mouse IFNA4 / IFNα4 / Interferon alpha-4 Protein (His Tag)
IFNAR1 / IFNAR Protein (His Tag) Cynomolgus IFNAR1 / IFNAR Protein
Mouse IFNA2 / Interferon alpha 2 Protein Cynomolgus IFNG / Interferon Gamma Protein (Native)
Rat IFN-alpha / IFNA1 / IFN Protein  

All Interferon Antibodies

Product name Product name
IFNGR1 / CD119 / IFN-gamma-R1 Antibody IFNAR2 Antibody
IFNGR1 / CD119 / IFN-gamma-R1 Antibody (Antigen Affinity Purified) IFNGR2 Antibody (Antigen Affinity Purified)
Interferon beta / IFN-beta / IFNB Antibody IFN beta Antibody (Antigen Affinity Purified)
IFNGR1 / CD119 / IFN-gamma-R1 Antibody IL-28B / IFN-lambda-3 Antibody (Antigen Affinity Purified)
IFNAR-1 / CRF2-1 Antibody IFNGR1 / CD119 Antibody
IFNAR-1 / CRF2-1 Antibody (Antigen Affinity Purified) IFNAR2 Antibody ( FITC )
IFNG / IFN-gamma Antibody IFNAR1 / IFNAR Antibody
IFNG / IFN-gamma Antibody (Antigen Affinity Purified) IFN beta Antibody
IFNAR2 / IFNABR Antibody IFNGR2 Antibody
IFNAR2 / IFNABR Antibody (Antigen Affinity Purified) IL-28B / IFN-lambda-3 Antibody
IFN-gamma / IFNG Antibody IFNGR1 / CD119 Antibody
IFNAR1 Antibody  

All Interferon ELISA Kits

Product name
IFNAR1 ELISA Pair Set, Mouse ELISA Pair Set
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"