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Integrin

Sino Biological offers a comprehensive set of tools for research on Integrin, including recombinant proteins, antibodies (rabbit mAbs, mouse mAbs, and rabbit pAbs), ELISA kits, and ORF cDNA clones.

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    Integrin Background

    Integrins are a family of cell surface receptors mediating interactions between cells and ECM (Extracellular Matrix) proteins. These interactions play a vital role in biological processes, including cell survival, growth, differentiation, migration, inflammatory responses, platelet aggregation, tissue repair and tumor invasion. Perturbing this coordination can lead to events such as malignant transformation. Signals from these adhesion receptors are integrated with those originating from growth factor receptors in order to organize the cytoskeleton, stimulate cell proliferation and rescue cells from matrix detachment and induced programmed cell death. These functions are critical in the regulation of gene expression, tissue development, inflammation, angiogenesis, tumor cell growth and metastasis. Integrins are composed of Alpha and Beta subunit molecules in close noncovalent association that form structural and functional bridges between the ECM and cytoskeletal linker proteins within a cell. The integrin family includes at least 24 heterodimers assembled from 18 alpha and 8 beta subunits. Integrin heterodimers contain binding sites for divalent magnesium and calcium that facilitate their binding of ligands.

    Integrin References

      1. Giancotti FG, et al. (1999) Integrin signaling. Science. 285(5430): 1028-32.
      2. Schlaepfer DD, et al. (1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature. 372(6508): 786-91.
      3. Schlaepfer DD, et al. (1998) Integrin signalling and tyrosine phosphorylation: just the FAKs? Trends Cell Biol. 8(4): 151-7.