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Insulin Receptor / CD220 / INSR Antibody, Rabbit PAb, Antigen Affinity Purified

  • Insulin Receptor / CD220 / INSR Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • Insulin Receptor / CD220 / INSR Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Human INSR/CD220 Antibody Product Information
Immunogen:Recombinant Human Insulin Receptor / CD220 / INSR protein (Catalog#11081-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Human Insulin Receptor / CD220 / INSR (rh Insulin Receptor / CD220 / INSR; Catalog#11081-H08H; NP_000199.2; Met 1-Lys 956). Insulin Receptor / CD220 / INSR specific IgG was purified by Human Insulin Receptor / CD220 / INSR affinity chromatography.
Human INSR/CD220 Antibody IHC Application Image
Insulin Receptor / CD220 / INSR Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human INSR in human kidney with rabbit polyclonal antibody (15µ g/mL, formalin-fixed paraffin embedded sections).
Insulin Receptor / CD220 / INSR Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human INSR in human pancreas with rabbit polyclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections).
Other INSR/CD220 Antibody Products
Insulin Receptor/INSR/CD220 Background

INSR (Insulin receptor), also known as CD220, is a transmembrane receptor that is activated by insulin. INSR belongs to theprotein kinase superfamily, and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually leads to an increase in the high affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibrobasts, spleen and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM).

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Catalog: 11081-RP02-200
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Datasheet & Documentation

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"