Inhibitor of Apoptosis (IAP)

Sino Biological provides a wide selection of tools for the Inhibitor of Apoptosis (IAP) protein related studies, including recombinant proteins, antibodies (mouse mAbs, rabbit mAbs, and rabbit pAbs), ELISA kits, and ORF cDNA clones.

Inhibitor of Apoptosis (IAP) Products

Please click the molecular formulas to find products that you are interested.

_* Being developed. Tell us your requirement so that the products of interest be placed on the priority list.

IAPs

cIAP1 / BIRC2	Survivin / BIRC5 / API4^*	XIAP / BIRC4
cIAP2 / BIRC3^*	ACLY

IAP Regulators

HTRA2 / PRSS25

SMAC / Diablo

Inhibitor of Apoptosis (IAP) Background

The Inhibitors of Apoptosis IAPs are a family of functionally- and structurally-related proteins, which serve as endogenous inhibitors of programmed cell death (apoptosis). The IAP proteins function by inhibiting the executioners of cell death (caspases), or by blocking the pathways that activate them. The inhibitors of apoptosis proteins function as ubiquitin E3 ligases and possess protein-protein interaction domains. They can promote the addition of ubiquitin to themselves and to the substrate proteins that they interact with either directly or indirectly through adaptor proteins. The balance between substrate and autoubiquitylation seems to be important for IAP activity.

Apoptosis is a cell suicide process with a major role in development and homeostasis in vertebrates and invertebrates. Inhibition of apoptosis enhances the survival of cancer cells and facilitates their escape from immune surveillance and cytotoxic therapies. Inhibitors of apoptosis proteins are expressed in the majority of human malignancies at elevated levels. IAPs play an active role in promoting tumor maintenance through the inhibition of cell death and participation in signaling pathways associated with malignancies. Inhibitors of apoptosis proteins present promising targets for the development of new cancer biomarkers and cancer therapeutics in hematological malignancies, as their increased expression levels in hematological malignancies.

Inhibitor of Apoptosis (IAP) Related Studies

Vucic D. (2008) Targeting IAP (inhibitor of apoptosis) proteins for therapeutic intervention in tumors. Curr Cancer Drug Targets. 8(2):110-7.
Fulda S. (2008) Inhibitor of apoptosis proteins in hematological malignancies. Leukemia. 23(3):467-76.
Mace PD, et al. (2010) Assembling the building blocks: structure and function of inhibitor of apoptosis proteins. Cell Death Differ. 17(1):46-53.