Inhibin beta A Protein (INHBA Protein)

Inhibin beta A Products

Inhibin beta A Protein, Recombinant

Molecule	Species	Description	Cat. No
Inhibin beta A/INHBA	Human	Inhibin beta A/INHBA Protein, Recombinant	10429-H08H
Inhibin beta A/INHBA	Mouse	Inhibin beta A/INHBA A chain Protein, Recombinant	50659-M08H

  10429-H08H:  Measured by its ability to bind human Follistatin in a functional ELISA.

Inhibin beta A cDNA Clone

Molecule	Species	Description	Cat. No
Inhibin beta A/INHBA	Human	Homo sapiens Inhibin beta A/INHBA cDNA Clone(NM_002192.2)	HG10429-M
Inhibin beta A/INHBA	Mouse	Mouse Inhibin beta A/INHBA cDNA Clone / ORF Clone	MG50659-M

Inhibin beta A Alternative Names

INHBA, EDF, FRP [Homo sapiens]

Inhba, activin, inhibin beta A [Mus musculus]

Inhibin beta A Related Areas

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>Inhibin beta A/INHBA

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>Inhibin beta A/INHBA

Inhibin beta A Related Products

Protein Products

Molecule	Species	Description
Inhibin beta B/INHBB	Human	Inhibin beta B/INHBB Protein, Recombinant
ALK-2/ACVR1	Human	ALK-2/ACVR1/Fc Protein, Recombinant
ALK-2/ACVR1	Mouse	ALK-2/ACVR1/Fc Protein, Recombinant
ACVR2A	Human	ACVR2A/Fc Protein, Recombinant
ACVR2B	Human	ACVR2B/Fc Protein, Recombinant
ACVR2B	Human	ACVR2B Protein, Recombinant
ACVR2B	Mouse	ACVR2B/Fc Protein, Recombinant
ACVR2B	Mouse	ACVR2B Protein, Recombinant
FSTL1/Follistatin Like 1	Human	FSTL1 Protein, Recombinant
FLRG/FSTL3	Mouse	FLRG/FSTL3 Protein, Recombinant

cDNA Clone Products

Molecule	Species	Description
Inhibin alpha/INHA	Human	Homo sapiens Inhibin alpha/INHA cDNA Clone(NM_002191.2)
Inhibin beta A/INHBA	Human	Homo sapiens Inhibin beta A/INHBA cDNA Clone(NM_002192.2)
Inhibin beta B/INHBB	Human	Homo sapiens Inhibin beta B/INHBB cDNA Clone(NM_002193.2)
Inhibin beta C/INHBC	Human	Homo sapiens Inhibin beta C/INHBC cDNA Clone(NM_005538.2)
Inhibin beta E/INHBE	Human	Homo sapiens Inhibin beta E/INHBE cDNA Clone(NM_031479.3)
ALK-2/ACVR1	Human	Homo sapiens ALK-2/ACVR1 transcript variant 2 cDNA Clone(NM_001111067.2)
ALK-4/ACVR1B	Human	Homo sapiens ALK-4/ACVR1B cDNA Clone(NM_004302.3)
ACVR2A	Human	Homo sapiens ACVR2A cDNA Clone(NM_001616.3)
ACVR2B	Human	Homo sapiens ACVR2B cDNA Clone(NM_001106.3)
Follistatin	Human	Homo sapiens Follistatin cDNA Clone(NM_013409.1)
FSTL1/Follistatin Like 1	Human	Homo sapiens FSTL1 cDNA Clone(NM_007085.4)

Inhibin beta A Background

Inhibin beta A/INHBA belongs to the TGF-beta family. This protein has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that Inhibin beta A/INHBA may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the Inhibin beta A/INHBA mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibin beta A/INHBA is involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.

Inhibin beta A Related Studies

1. Tanimoto K, et al. (1992) Structure and sequence analysis of the human activin beta A subunit gene. DNA Seq. 2 (2): 103-10.
2. Welt C, et al. (2002) Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. Exp Biol Med. 227 (9): 724-52.
3. Xu J, et al. (1995) Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J Biol Chem. 270 (11): 6308-13.