Inhibin beta B Protein (INHBB Protein)

Inhibin beta B Products

Inhibin beta B Protein, Recombinant

Molecule	Species	Description	Cat. No
Inhibin beta B/INHBB	Human	Inhibin beta B/INHBB Protein, Recombinant	10814-H08H

Inhibin beta B cDNA Clone

Molecule	Species	Description	Cat. No
Inhibin beta B/INHBB	Human	Homo sapiens Inhibin beta B/INHBB cDNA Clone(NM_002193.2)	HG10814-M

Inhibin beta B Alternative Names

INHBB, MGC157939 [Homo sapiens]

Inhbb, activin [Mus musculus]

Inhibin beta B Related Areas

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>Inhibin beta B/INHBB

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>Inhibin beta B/INHBB

Inhibin beta B Related Products

Protein Products

Molecule	Species	Description
Inhibin beta A/INHBA	Human	Inhibin beta A/INHBA Protein, Recombinant
ALK-2/ACVR1	Human	ALK-2/ACVR1/Fc Protein, Recombinant
ALK-2/ACVR1	Mouse	ALK-2/ACVR1/Fc Protein, Recombinant
ACVR2A	Human	ACVR2A/Fc Protein, Recombinant
ACVR2B	Human	ACVR2B/Fc Protein, Recombinant
ACVR2B	Human	ACVR2B Protein, Recombinant
ACVR2B	Mouse	ACVR2B/Fc Protein, Recombinant
ACVR2B	Mouse	ACVR2B Protein, Recombinant
FSTL1/Follistatin Like 1	Human	FSTL1 Protein, Recombinant
FLRG/FSTL3	Mouse	FLRG/FSTL3 Protein, Recombinant

cDNA Clone Products

Molecule	Species	Description
Inhibin alpha/INHA	Human	Homo sapiens Inhibin alpha/INHA cDNA Clone(NM_002191.2)
Inhibin beta A/INHBA	Human	Homo sapiens Inhibin beta A/INHBA cDNA Clone(NM_002192.2)
Inhibin beta C/INHBC	Human	Homo sapiens Inhibin beta C/INHBC cDNA Clone(NM_005538.2)
Inhibin beta E/INHBE	Human	Homo sapiens Inhibin beta E/INHBE cDNA Clone(NM_031479.3)
ALK-2/ACVR1	Human	Homo sapiens ALK-2/ACVR1 transcript variant 2 cDNA Clone(NM_001111067.2)
ALK-4/ACVR1B	Human	Homo sapiens ALK-4/ACVR1B cDNA Clone(NM_004302.3)
ACVR2A	Human	Homo sapiens ACVR2A cDNA Clone(NM_001616.3)
ACVR2B	Human	Homo sapiens ACVR2B cDNA Clone(NM_001106.3)
Follistatin	Human	Homo sapiens Follistatin cDNA Clone(NM_013409.1)
FSTL1/Follistatin Like 1	Human	Homo sapiens FSTL1 cDNA Clone(NM_007085.4)

Inhibin beta B Background

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin beta B/INHBB has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of Inhibin beta B/INHBB have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that Inhibin beta B/INHBB may be both a growth/differentiation factor and a hormone. INHBB is a subunit of both activin and inhibin, two closely related glycoproteins with opposing biological effects. Inhibin beta B/INHBB is involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.

Inhibin beta B Related Studies

1. Feng ZM, et al. (1989) Characterization and regulation of testicular inhibin beta-subunit mRNA. Mol Endocrinol. 3 (6): 939-48.
2. Bernard DJ, et al. (2002) Inhibin binding protein (InhBP/p120), betaglycan, and the continuing search for the inhibin receptor. Mol Endocrinol. 16 (2): 207-12.
3. Lejeune H, et al. (1997) Stimulating effect of both human recombinant inhibin A and activin A on immature porcine Leydig cell functions in vitro. Endocrinology. 138 (11): 4783-91.