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InfluenzaNonstructural Protein 1 (NS1)

Sino Biological offers a comprehensive set of tools (recombinant proteins, antibodies, ELISA kits, cDNA clones) directed towards influenza A H1N1 antigens, including hemagglutinin (HA), neuraminidas (NA), nucleoprotein (NP), matrix protein 1 (M1), NS1, NS2, etc.     

  Influenza NP,M1 sequence analysis among different subtypes and strains

Influenza  Nonstructural Protein 1 (NS1Protein, Antibody, ELISA Kit and cDNA CloneProducts

NS1ProteinNS1AntibodyNS1ELISA KitNS1cDNA Clone
ProductMoleculeCat No.Package/Price 
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural / NS1 Protein (His Tag)NS140011-V07E-50
40011-V07E-100
50 µg/$178
100 µg/$298
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InfluenzaNonstructural Protein 1 (NS1) Background

The Influenza non-structural protein 1 (NS1) is created by the internal protein encoding, linear negative-sense, single stranded RNA, NS gene segment, which found in Influenza virus A, Influenza virus B and Influenza virus C, and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The NS1 is a phosphoprotein and has two nuclear localization signals. In the nucleus, the NS1 interferes with the splicing as well as the nuclear export of cellular mRNAs. In the later time of the infection, the NS1 is present in the cytoplasm and associates with the polysomes. The NS1 binds to the 5'UTR of some viral mRNAs and stimulates translation. One intensively described nuclear function of the influenza A NS1 (A/NS1) protein is the inhibition of the splicing and nucleo-cytoplasmic export of cellular mRNAs and. The A/NS1 protein also inhibits the splicing and, hence, export of its own collinear mRNA when expressed by the viral RNA polymerase . This finding indicates that the NS1 protein can act on the processing of cellular and viral mRNA transcripts.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"