Sino Biological offers a comprehensive set of tools (recombinant proteins, antibodies, ELISA kits, cDNA clones) directed towards influenza A H1N1 antigens, including hemagglutinin (HA), neuraminidas (NA), nucleoprotein (NP), matrix protein 1 (M1), NS1, NS
|Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Matrix protein 1 / M1 Protein (His Tag)||M1|
|Influenza A H7N9 (A/Anhui/1/2013) Matrix protein 1 / M1 Protein (His Tag)||M1|
|Influenza A H1N1 (A/Brevig Mission/1/1918) Matrix protein 1 / M1 Protein (His Tag)||M1|
|Influenza A H3N2 (A/Aichi/2/1968) Matrix protein 1 / M1 Protein (His Tag)||M1|
Influenza virus matrix protein 1 (M1) has been shown to plays important roles during replication, assembly and budding of the virus. The M1 protein of influenza virus regulates the bi-directional transport of ribonucleoprotein (RNP) into and out of the nucleus. At the beginning of infection, the incoming RNP is transported into the nucleus only after detachment from M1, where RNP is involved in transcription/replication of the viral genome. In the late stage of infection, M1 inhibits viral RNA polymerase activity by binding to RNP, which may be a signal for RNP-transport from the nucleus to the cell surface. Finally, M1 mediates the association of RNP with viral envelope glycoproteins on the inner surface of the cytoplasmic membrane, which then promotes the virion formation and budding. The matrix protein M1, the organizer of assembly of influenza virus, interacts with other virus components and with cellular membranes. It has been proposed that M1 binding to lipids is mediated by its polybasic region. It been identified heat shock cognate protein 70 (Hsc70) is directly associated with M1 and therefore is required for viral production. The interactions of M1 with viral envelope proteins are essential to direct M1 to the plasma membrane for influenza virus particle release.