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>Influenza M1 Protein & Antibody (Matrix Protein 1)
Influenza M1 Protein & Antibody (Matrix Protein 1) H7N9 Protein & Antibody New !
Matrix protein 1
Influenza M1 Products
Influenza M1 Protein, Recombinant
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Influenz M1||Influenza A H1N1 Virus||Influenza A Virus A/Puerto Rico/8/34/Mount Sinai (H1N1) M1 Protein, Recombinant||40010-V07E|
Influenza A Matrix Protein 1 (M1) Antibody
Description //For Detailed Info. and Price------CLICK!
Influenza A H1N1 Virus
Influenza A Virus A/Puerto Rico/8/34/Mount Sinai (H1N1) M1 Antibody
Influenza M1 Background
Influenza virus matrix protein 1 (M1) has been shown to plays important roles during replication, assembly and budding of the virus. The M1 protein of influenza virus regulates the bi-directional transport of ribonucleoprotein (RNP) into and out of the nucleus. At the beginning of infection, the incoming RNP is transported into the nucleus only after detachment from M1, where RNP is involved in transcription/replication of the viral genome. In the late stage of infection, M1 inhibits viral RNA polymerase activity by binding to RNP, which may be a signal for RNP-transport from the nucleus to the cell surface. Finally, M1 mediates the association of RNP with viral envelope glycoproteins on the inner surface of the cytoplasmic membrane, which then promotes the virion formation and budding. The matrix protein M1, the organizer of assembly of influenza virus, interacts with other virus components and with cellular membranes. It has been proposed that M1 binding to lipids is mediated by its polybasic region. It been identified heat shock cognate protein 70 (Hsc70) is directly associated with M1 and therefore is required for viral production. The interactions of M1 with viral envelope proteins are essential to direct M1 to the plasma membrane for influenza virus particle release.
Influenza M1 Related Studies
- Itoh M, et al. (1997) Structure, function and regulation of expression of influenza virus matrix M1 protein. Nihon Rinsho. 55(10): 2581-6.
- Watanabe K, et al. (2006) Identification of Hsc70 as an influenza virus matrix protein (M1) binding factor involved in the virus life cycle. FEBS Lett. 580(24): 5785-90.
- Huang S, et al. (2009) Influenza A virus matrix protein 1 interacts with hTFIIIC102-s, a short isoform of the polypeptide 3 subunit of human general transcription factor IIIC. Arch Virol. 154(7): 1101-10.
- Thaa B, et al. (2009) The polybasic region is not essential for membrane binding of the matrix protein M1 of influenza virus. Virology. 383(1): 150-5.
- Wang D, et al. (2010) The lack of an inherent membrane targeting signal is responsible for the failure of the matrix (M1) protein of influenza A virus to bud into virus-like particles. J Virol. 84(9): 4673-81.