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Influenza Hemagglutinin (HA) Protein Structure


Q1: Structure of Influenza

Influenza Viruses is a viral infection of the respiratory and pulmonary system generally accompanied by fever. It is hard to prevent influenza because it is contracted simply by the act of breathing. There are necleopretein, P protein and RNA in the center of a influenza virus and the center domain is surrounded by capsid and lipid envelope from inside to outside. On the surface of influenza, there are Hemagglutinin (HA) and Neuraminidase (NA), both of which serve as antigenic proteins. In a word, the influenza virus is composed of a lipid bilayer with hemagglutinin and neuraminidase attached to it.influenza virus


Q2: Structure of Hemagglutinin (HA)

Hemagglutinin (HA) is a glycoprotein that binds the virus to the cell being infected. The hemagglutinin molecule is actually a combination of three identical proteins (shown here as gray, green, and purple) that are bound together to form an elongated cylindrical shape. Hemagglutinin consists of a globular head and a stem. The globular head consists of three chains, Chains A, C, and E. The stem of the protein consists of three chains as well, Chains B, D, and F. The head of the protein has been noted to vary in structure and function where the stem, or glycan, has been noted to be more conserved in structure and function. The function of chains A, C, and E is the binding of influenza to pulmonary cells and the start of endocytosis.hemagglutinin


Q3: Structure of Neuraminidase (NA)

Neuraminidase (NA)is an enzyme that helps the virus to breach cell walls. Neuraminidase is also known as sialidase because it breaks the linkages between sialic acid and cellular glycoproteins and glycolipids found in cell walls. Neuraminidase forms mushroom-like projections on the surface of the influenza virus. The top consists of four identical proteins with a roughly spherical shape. The picture below shows how each of these subunits is rotated by 90 degrees relative to the center of the arrangement.

structure of neuraminidase


Influenza Research Reagents (Hot!)

Influenza virus antigen protein
Product Name Cat No.
Influenza H1N1 (A/California/07/2009) Hemagglutinin 11085-V08H
Influenza H1N1 (A/Puerto Rico/8/1934) Hemagglutinin 11684-V08H
Influenza H1N1 (A/California/04/2009) Hemagglutinin 11055-V08H
Influenza H1N1 (A/California/04/2009) Hemagglutinin 11055-V08B
Influenza H3N2 (A/Aichi/2/1968) Hemagglutinin 11707-V08H
Influenza H3N2 (A/Brisbane/10/2007) Hemagglutinin 11056-V08H
Influenza H5N1 (A/Anhui/1/2005) Hemagglutinin 11048-V08H1
Influenza H3N2 Virus Hemagglutinin Protein 40043-V08H
Influenza H7N9 (A/Anhui/1/2013) Hemagglutinin Protein 40103-V08B
Influenza H1N1 (A/Brisbane/59/2007) Hemagglutinin 11052-V08H
Influenza H5N1 (A/VietNeuraminidasem/1194/2004) Hemagglutinin 11062-V08H1
Influenza H7N9 (A/Anhui/1/2013) Hemagglutinin Protein 40103-V08H
Influenza H5N1 (A/Anhui/1/2005) Hemagglutinin 11048-V08H4
Influenza H1N1 (A/California/07/2009) Hemagglutinin Protein 11085-V08B
Influenza H1N1 Nucleoprotein Protein 11675-V08B
Influenza H1N1 (A/California/07/09) Nucleoprotein Protein 40205-V08B
Influenza H1N1 (A/California/04/2009 )Neuraminidase Protein (Active) 11058-V07B
Influenza H5N1 Neuraminidase (Active) 11676-VNAHC
Influenza H5N1 (A/Hubei/2011) Neuraminidase Protein (Active) 40018-V07H
Influenza H1N1 (A/Puerto Rico/8/34/Mount SiNeuraminidasei) Matrix Protein 1 40010-V07E
Influenza virus antigen antibody
Product Name Cat No.
Influenza H1N1 (Swine Flu 2009) Hemagglutinindy Antibo 11055-MM01
Influenza H1N1 (Swine Flu 2009) Hemagglutinin Antibody 11055-RM05
Influenza H7N9 Hemagglutinin Antibody, Rabbit Pab 40103-RP02
Influenza H1N1 (Swine) Hemagglutinin Antibody 11055-MM09
Influenza H1N1 Hemagglutinin Antibody 11684-RP01
Influenza H1N1 (Swine Flu 2009) Hemagglutinin Antibody 11055-RP02
Influenza H5N1 (Avian Flu) Hemagglutinin Antibody 11048-MM01
Influenza Virus Hemagglutinin Antibody, Rabbit MAb 86001-RM01
Influenza H3N2 Hemagglutinin Antibody 11056-MM03
Influenza H1N1 (Swine Flu 2009) Neuraminidase Antibody 11058-R001