Influenza A Virus Hemagglutinin / HA Antibody, Rabbit MAb

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Influenza A Virus Hemagglutinin / HA Antibody, Rabbit MAb (Rabbit Monoclonal antibody) General Information

Product name
Influenza A Virus Hemagglutinin / HA Antibody, Rabbit MAb
Validated applications
WB,ELISA,IHC-P,FCM,ICC/IF,IP (Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
Application notes
(Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
Specificity
Influenza Hemagglutinin / HA
Has cross-reactivity in ELISA with
H1N1 (A/Beijing/22808/2009) HA
H1N1 (A/Brevig Mission/1/1918) HA
H1N1 (A/Brisbane/59/2007) HA
H1N1 (A/California/04/2009) HA
H1N1 (A/California/07/2009) HA
H1N1 (A/England/195/2009) HA
H1N1 (A/New Caledonia/20/1999) HA
H1N1 (A/New York/18/2009) HA
H1N1 (A/Ohio/07/2009) HA
H1N1 (A/Ohio/UR06-0091/2007) HA
H1N1 (A/Puerto Rico/8/1934) HA
H1N1 (A/Solomon Islands/3/2006) HA
H1N1 (A/Texas/05/2009) HA
H1N1 (A/WSN/1933) HA
H1N2 (A/swine/Guangxi/13/2006) HA
H1N3 (A/duck/NZL/160/1976) HA
H2N2 (A/Canada/720/2005) HA
H2N2 (A/Japan/305/1957) HA
H3N2 (A/Aichi/2/1968) HA
H3N2 (A/Brisbane/10/2007) HA
H3N2 (A/Perth/16/2009) HA
H3N2 (A/Wisconsin/67/X-161/2005) HA
H3N2 (A/Wyoming/03/2003) HA
H4N4 (A/mallard duck/Alberta/299/1977) HA
H4N6 (A/mallard/Ohio/657/2002) HA
H4N6 (A/Swine/Ontario/01911-1/99) HA
H4N8 (A/chicken/Alabama/1/1975) HA
H5N1 (A/Anhui/1/2005) HA
H5N1 (A/Anhui/1/2005) HA2 Sub-unit
H5N1 (A/bar-headed goose/Qinghai/14/2008) HA
H5N1 (A/barnswallow/HongKong/D10-1161/2010) HA1 Subunit
H5N1 (A/Cambodia/R0405050/2007) HA
H5N1 (A/Cambodia/S1211394/2008) HA
H5N1 (A/chicken/India/NIV33487/2006) HA
H5N1 (A/Common magpie/Hong Kong/2256/2006) HA
H5N1 (A/duck/Hunan/795/2002) HA
H5N1 (A/Egypt/2321-NAMRU3/2007) HA
H5N1 (A/Egypt/N05056/2009) HA
H5N1 (A/goose/Guiyang/337/2006) HA
H5N1 (A/Hong kong/213/03) HA
H5N1 (A/Hong Kong/483/97) HA
H5N1 (A/Hubei/2011) HA
H5N1 (A/Indonesia/5/2005) HA
H5N1 (A/Japanese white-eye/Hong Kong/1038/2006) HA
H5N1 (A/turkey/Turkey/1/2005) HA
H5N1 (A/Viet Nam/1203/2004) HA
H5N1 (A/Vietnam/1194/2004) HA
H5N1 (A/whooper swan/Mongolia/244/2005) HA
H5N1 (A/Xinjiang/1/2006) HA
H5N2 (A/American green-winged teal/California/HKWF609/07) HA
H5N3 (A/duck/Hokkaido/167/2007) HA
H5N8 (A/duck/NY/191255-59/2002) HA
H6N1 (A/northern shoveler/California/HKWF115/2007) HA
H6N4 (A/chicken/HongKong/17/77) HA
H7N7 (A/chicken/Netherlands/1/03) HA
H7N7 (A/Netherlands/219/03) HA
H7N8 (A/mallard/Netherlands/33/2006) HA
H7N9 (A/Anhui/1/2013) HA
H7N9 (A/Hangzhou/1/2013) HA
H7N9 (A/Hangzhou/3/2013) HA
H7N9 (A/Pigeon/Shanghai/S1069/2013) HA
H7N9 (A/Shanghai/1/2013) HA
H7N9 (A/Shanghai/2/2013) HA
H7N9 (A/Shanghai/4664T/2013) HA
H7N9 (A/Zhejiang/1/2013) HA
H8N4 (A/pintail duck/Alberta/114/1979) HA
H9N2 (A/Chicken/Hong Kong/G9/97) HA
H9N2 (A/Guinea fowl/Hong Kong/WF10/99) HA
H9N2 (A/Hong Kong/1073/99) HA
H9N2 (A/Hong Kong/35820/2009) HA
H10N3 (A/duck/Hong Kong/786/1979) HA
H10N3 (A/mallard/Minnesota/Sg-00194/2007) HA
H10N9 (A/duck/HongKong/562/1979) HA
H11N2 (A/duck/Yangzhou/906/2002) HA
H11N9 (A/mallard/Alberta/294/1977) HA
H12N1 (A/mallard duck/Alberta/342/1983) HA
H12N5 (A/green-winged teal/ALB/199/1991) HA
H13N8 (A/black-headed gull/Netherlands/1/00) HA
H15N8 (A/duck/AUS/341/1983) HA
H16N3 (A/black-headed gull/Sweden/5/99) HA
No cross-reactivity in ELISA with
H1N1 (A/Brevig Mission/1/1918) HA
H1N1 (A/California/04/2009) HA1 Sub-unit,
Influenza B (B/Florida/4/2006) HA
Immunogen
Recombinant H1N1 HA protein
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Influenza A virus H1N1 Hemagglutinin extracellular domain.
Source
Monoclonal Rabbit IgG Clone #2
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Influenza A Virus Hemagglutinin / HA Antibody, Rabbit MAb (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
WB his antibody can be used at 1:500-1:1000 with the appropriate secondary reagents to detect H1N1 HA in WB.
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Hemagglutinin / HA Background Information

The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane.The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Full Name
Harvey rat sarcoma viral oncogene homolog
References
  • White JM, Hoffman LR, Arevalo JH, et al. (1997). ""Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin"". In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses.
  • Suzuki Y (March 2005). ""Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses"". Biol. Pharm. Bull. 28 (3): 399–408.
  • Senne DA, Panigrahy B, Kawaoka Y, et al. (1996). ""Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential"". Avian Dis. 40 (2): 425–37
  • Influenza A virus Utilizes a Suboptimal Kozak Sequence to Fine-tune Virus Replication and Host Response
    Author
    Wang, J;Peng, Y;Zhao, L;Cao, M;Hung, T;Deng, T;
    Year
    2014
    Journal
    J. Gen. Virol.
  • New insights into the non-conserved non-coding region of the subtype-determinant HA and NA segments of influenza A viruses
    Author
    Zhao, L;Peng, Y;Zhou, K;Cao, M;Wang, J;Wang, X;Jiang, T;Deng, T;
    Year
    2014
    Journal
    J. Virol.
  • Synthesis and anti-influenza virus activity of 4-oxo- or thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-ones
    Author
    Jang, YJ;Achary, R;Lee, HW;Lee, HJ;Lee, CK;Han, SB;Jung, YS;Kang, NS;Kim, P;Kim, M;
    Year
    2014
    Journal
    Antiviral Res.
    Application
    WB
  • Protective neutralizing influenza antibody response in the absence of T follicular helper cells
    Author
    Miyauchi, K;Sugimoto-Ishige, A;Harada, Y;Adachi, Y;Usami, Y;Kaji, T;Inoue, K;Hasegawa, H;Watanabe, T;Hijikata, A;Fukuyama, S;Maemura, T;Okada-Hatakeyama, M;Ohara, O;Kawaoka, Y;Takahashi, Y;Takemori, T;Kubo, M;
    Year
    2016
    Journal
    Nat. Immunol.
    Application
    ELISA
  • The dual roles of the HA segment-specific noncoding nucleotides in the extended duplex region of the influenza A virus RNA promoter
    Author
    Wang, J;Li, J;Zhao, L;Cao, M;Deng, T;
    Year
    2016
    Journal
    J. Virol.
    Application
    WB

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