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Influenza A H6N4 (A/chicken/Hong Kong/17/1977) Hemagglutinin / HA Protein (His Tag)

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H6N4 HA Protein Product Information
Synonym:Hemagglutinin, HA
Protein Construction:A DNA sequence encoding the HA (CAC84244.1) (Met1-Gln529) was expressed with a polyhistidine tag at the C-terminus.
Expressed Host:Baculovirus-Insect Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
H6N4 HA Protein QC Testing
Purity:> 90 % as determined by SDS-PAGE.
Bio-Activity:Measured by its ability to agglutinate guinea pig red blood cells.
HA titer is 0.5-2μg/mL for 1%GRBC
Endotoxin:< 1.0 EU per μg protein as determined by the LAL method.
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Ile 17
Molecule Mass:The recombinant HA consists 464 amino acids and predicts a molecular mass of 52.6 kDa.
Formulation:Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 %glycerol, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
H6N4 HA Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
H6N4 HA Protein SDS-PAGE
Influenza A H6N4 (A/chicken/Hong Kong/17/1977) Hemagglutinin / HA Protein (His Tag)

HA Related Pathways

    Other HA Recombinant Protein Products
    HA Background

    The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane.The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA0, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA0) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.

    H6N4 HA References
  • White JM, Hoffman LR, Arevalo JH, et al. (1997). "Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin". In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses.
  • Suzuki Y (March 2005). "Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses". Biol. Pharm. Bull. 28 (3): 399–408.
  • Senne DA, Panigrahy B, Kawaoka Y, et al. (1996). "Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential". Avian Dis. 40 (2): 425–37
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    • Influenza A H6N4 (A/chicken/Hong Kong/17/1977) Hemagglutinin / HA Protein (His Tag)
      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.