IkB alpha (Protein|Antibody|cDNA Clone|ELISA Kit)

All IkB alpha reagents are produced in house and quality controlled, including 7 IkB alpha Antibody, 2 IkB alpha ELISA, 32 IkB alpha Gene, 2 IkB alpha IPKit, 1 IkB alpha Protein, 1 IkB alpha qPCR. All IkB alpha reagents are ready to use.

Recombinant IkB alpha proteins are expressed by E. coli with fusion tags as N-His.

IkB alphaantibodies are validated with different applications, which are ELISA, ELISA(Det), FCM, ICC/IF, IF, WB, IP, ELISA(Cap).

IkB alphacDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IkB alpha of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

IkB alphaELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.

IkB alpha Protein (1)

Species

IkB alpha Protein, Human, Recombinant (His Tag)

12045-H07E

Expression host: E. coli

Human IkB alpha/NFKBIA Protein 9942
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IkB alpha Antibody (7)

Anti-IkB alpha Antibody

12045-MM02

Application: ELISA,ELISA(Det),FCM,ICC/IF,IF

Clonality: MAb

Human IkB alpha/NFKBIA Immunofluorescence(IF) 2879

Anti-IkB alpha Antibody (FITC)

12045-MM02-F

Application: FCM,ICC/IF,IF

Clonality: MAb

Human IkB alpha/NFKBIA Flow Cytometry (FC) 2670

Anti-IkB alpha Antibody

12045-R056

Application: ELISA(Cap)

Clonality: MAb

Anti-IkB alpha Antibody

12045-RP02

Application: WB,ELISA,IP

Clonality: PAb

Human IkB alpha/NFKBIA Western blot (WB) 13461

Anti-IkB alpha Antibody

12045-R116

Application: WB,ELISA,IP

Clonality: MAb

Human IkB alpha/NFKBIA Western blot (WB) 13460

Anti-IkB alpha Antibody

12045-RP01

Application: ELISA

Clonality: PAb

Anti-IkB alpha Antibody

12045-MM03

Application: ELISA

Clonality: MAb

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IkB alpha ELISA KIT & match antibody elias pair set ( 2 )

IkB alpha ELISA Kit, Human

KIT12045

Sensitivity: 3.6 pg/mL

Human IkB alpha/NFKBIA ELISA Kit Standard Curve 112

IkB alpha Matched ELISA Antibody Pair Set,Human

SEK12045

Assay Range: 12.5 pg/ml

Human IkB alpha/NFKBIA ELISA Pair Set Standard Curve 13955

IkB alpha cDNA Clone (32)

Rat
Mouse
Human

IkB alpha qPCR Primer (1)

IkB alpha IP Kit (2)

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper functioning. Signal-induced degradation of I kappa B alpha exposes the nuclear localization signal of NF-kappa B, thus allowing it to translocate into the nucleus and activate transcription from responsive genes. An autoregulatory loop is established when NF-kappa B induces expression of the I kappa B alpha gene and newly synthesized I kappa B alpha accumulates in the nucleus where it negatively regulates NF-kappa B-dependent transcription. As part of this post-induction repression, the nuclear export signal on I kappa B alpha mediates transport of NF-kappa B-I kappa B alpha complexes from the nucleus to the cytoplasm. Deletion of NFKBIA has an effect that is similar to the effect of EGFR amplification in the pathogenesis of glioblastoma and is associated with comparatively short survival. Polymorphisms in NFKBIA may be important in pre-disposition to and outcome after treatment, of multiple myeloma (MM). The NFKBIA gene product, IkappaBalpha, binds to NF-kappaB preventing its activation and is important in mediating resistance to apoptosis in B-cell lymphoproliferative diseases.

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