IkB alpha / NFKBIA Protein & Antibody

I-kappa-B-alpha / Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

IkB alpha / NFKBIA Products

IkB alpha / NFKBIA Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IkB alpha/NFKBIA	Human	IkB alpha/NFKBIA Protein, Recombinant	12045-H07E

IkB alpha / NFKBIA Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IkB alpha / NFKBIA	WB, ELISA, ICC/IF IF	IkB alpha / NFKBIA Antibody	12045-MM02
Human IkB alpha / NFKBIA	WB, ELISA, ICC/IF	IkB alpha / NFKBIA Antibody, Mouse Mab	12045-MM02-F
Human IkB alpha / NFKBIA	WB, ELISA	IkB alpha / NFKBIA Antibody, Mouse Mab	12045-MM03
Human IkB alpha / NFKBIA	WB, ELISA	IkB alpha / NFKBIA Antibody (Antigen Affinity Purified)	12045-RP02
Human IkB alpha / NFKBIA	WB, ELISA	IkB alpha / NFKBIA Antibody	12045-R116

IkB alpha / NFKBIA cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IkB alpha/NFKBIA	Human	Homo sapiens NFKBIA cDNA Clone	HG12045-G

IkB alpha / NFKBIA Related Areas

Signal Transduction>>NFkB pathway>>IkB alpha/NFKBIA

Cancer>>NFkB pathway>>IkB alpha/NFKBIA

IkB alpha / NFKBIA Alternative Names

IkB alpha, NFKBIA, IKBA, MAD-3, NFKBI [Homo sapiens]

IkB alpha, Nfkbia, AI462015, Nfkbi [Mus musculus]

IkB alpha / NFKBIA Background

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper functioning. Signal-induced degradation of I kappa B alpha exposes the nuclear localization signal of NF-kappa B, thus allowing it to translocate into the nucleus and activate transcription from responsive genes. An autoregulatory loop is established when NF-kappa B induces expression of the I kappa B alpha gene and newly synthesized I kappa B alpha accumulates in the nucleus where it negatively regulates NF-kappa B-dependent transcription. As part of this post-induction repression, the nuclear export signal on I kappa B alpha mediates transport of NF-kappa B-I kappa B alpha complexes from the nucleus to the cytoplasm. Deletion of NFKBIA has an effect that is similar to the effect of EGFR amplification in the pathogenesis of glioblastoma and is associated with comparatively short survival. Polymorphisms in NFKBIA may be important in pre-disposition to and outcome after treatment, of multiple myeloma (MM). The NFKBIA gene product, IkappaBalpha, binds to NF-kappaB preventing its activation and is important in mediating resistance to apoptosis in B-cell lymphoproliferative diseases.

IkB alpha / NFKBIA Related Studies

1. Verma IM, et al. (1995) Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 9 (22): 2723–35.
2. Jacobs MD, et al. (1998) Structure of an IkappaBalpha/NF-kappaB complex. Cell 95 (6): 749–58.
3. Hay RT, et al. (1999) Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha. Philos Trans R Soc Lond B Biol Sci. 354(1389): 1601-9.
4. Spink CF, et al. (2007) Haplotypic structure across the I kappa B alpha gene (NFKBIA) and association with multiple myeloma. Cancer Lett. 246(1-2): 92-9.
5. Bredel M, et al. (2011) NFKBIA deletion in glioblastomas. N Engl J Med. 364(7): 627-37.