IZUMO4

Izumo is a sperm membrane protein which plays a key role in the fusion in the mouse. It has an Immunoglobulin (Ig) domain and an N-terminal domain for which neither the functions nor homologous sequences are known. Up to now, there four members has an N-terminal domain with significant homology to the N-terminal domain of Izumo. We call this domain Izumo domain. The four proteins are Izumo 1, 2, 3, and 4. Izumo domain possesses the ability to form dimers, whereas the transmembrane domain or the cytoplasmic domain or both of Izumo 1 are required for the formation of multimers of higher order. Izumo 1-3 are transmembrane proteins expressed specifically in the testis, and Izumo 4 is a soluble protein expressed in the testis and in other tissues. Izumo 1, 3, and izumo4 formed protein complexes on sperm, Izumo 1 forming several larger complexes and Izumo 3 and izumo4 forming a single larger complex. Co-immunoprecipitation studies showed the presence of other sperm proteins associated with Izumo 1, suggesting Izumo 1 forms a multiprotein membrane complex.

IZUMO4 Related Areas

Immunology>>Adhesion Molecule>>IZUMO4

IZUMO4 Alternative Names

UNQ831/PRO1758, C19orf36, IMAGE:4215339, izumo sperm-egg fusion protein 4, putative SAMP14 binding protein variant 1, putative SAMP14 binding protein variant 2, sperm 22 kDa protein c113 [Homo sapiens]

9030607L17Rik, AI550407, izumo sperm-egg fusion protein 4 [Mus musculus]

Human IZUMO4 Protein General Information

 

• Protein names: Izumo sperm-egg fusion protein 4
• Sequence length: 232 AA.
• Sequence similarities: Izumo4 elongs to the Izumo family.
• Miscellaneous: Izumo is the name of a Japanese shrine to marriage.
• Subcellular location: Secreted
• Tissue specificity: Izumo4 is detected in sperm.
• Sequence caution: The sequence AAH10443.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

General information above from UniProt