IZUMO4 / C19ORF36 Protein

IZUMO family member 4

IZUMO4 Products

IZUMO4 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
IZUMO4	Human	IZUMO4 / C19orf36 Protein, Recombinant	13249-H02H

IZUMO4 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
IZUMO4	Human	Human C19ORF36 Gene cDNA Clone / ORF Clone	HG13249-G

IZUMO4 Related Areas

Immunology>>Adhesion Molecule>>IZUMO4

IZUMO4 Alternative Names

UNQ831/PRO1758, C19orf36, IMAGE:4215339, izumo sperm-egg fusion protein 4, putative SAMP14 binding protein variant 1, putative SAMP14 binding protein variant 2, sperm 22 kDa protein c113 [Homo sapiens]

9030607L17Rik, AI550407, izumo sperm-egg fusion protein 4 [Mus musculus]

IZUMO4 Background

Izumo is a sperm membrane protein which plays a key role in the fusion in the mouse. It has an Immunoglobulin (Ig) domain and an N-terminal domain for which neither the functions nor homologous sequences are known. Up to now, there four members has an N-terminal domain with significant homology to the N-terminal domain of Izumo. We call this domain Izumo domain. The four proteins are Izumo 1, 2, 3, and 4. Izumo domain possesses the ability to form dimers, whereas the transmembrane domain or the cytoplasmic domain or both of Izumo 1 are required for the formation of multimers of higher order. Izumo 1-3 are transmembrane proteins expressed specifically in the testis, and Izumo 4 is a soluble protein expressed in the testis and in other tissues. Izumo 1, 3, and 4 formed protein complexes on sperm, Izumo 1 forming several larger complexes and Izumo 3 and 4 forming a single larger complex. Co-immunoprecipitation studies showed the presence of other sperm proteins associated with Izumo 1, suggesting Izumo 1 forms a multiprotein membrane complex.

IZUMO4 Related Studies

1. Gerhard DS, et al. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14(10B):2121-7.
2. Lamesch P, et al. (2007) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics. 89(3):307-15.
3. Ellerman DA, et al. (2009) Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Mol Reprod Dev. 76(12):1188-99.