IZUMO1

Izumo is a sperm membrane protein which plays a key role in the fusion in the mouse. It has an Immunoglobulin (Ig) domain and an N-terminal domain for which neither the functions nor homologous sequences are known. Up to now, there four members has an N-terminal domain with significant homology to the N-terminal domain of Izumo. We call this domain Izumo domain. The four proteins are Izumo 1, 2, 3, and 4. Izumo domain possesses the ability to form dimers, whereas the transmembrane domain or the cytoplasmic domain or both of Izumo 1 are required for the formation of multimers of higher order. Izumo 1-3 are transmembrane proteins expressed specifically in the testis, and Izumo 4 is a soluble protein expressed in the testis and in other tissues. Izumo 1, 3, and 4 formed protein complexes on sperm, Izumo 1 forming several larger complexes and Izumo 3 and 4 forming a single larger complex. Izumo1 is essential for sperm-egg plasma membrane binding and fusion.

IZUMO1 Alternative Names

IZUMO, OBF, izumo sperm-egg fusion protein 1, oocyte binding/fusion factor, sperm-specific protein Izumo [Homo sapiens]

1700058F15Rik, Izumo, OBF, izumo sperm-egg fusion protein 1, oocyte binding/fusion factor, sperm-specific protein Izumo [Mus musculus]

Summaries for IZUMO1

Entrez Gene summary for IZUMO1:

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 ).

OMIM - description for IZUMO1:

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005).

Human IZUMO1 Protein General Information

 

• Protein names: Recommended name: Izumo sperm-egg fusion protein 1
  Short name = IZUMO1
• Sequence length: 350 AA.
• Domain: Immunoglobulin domain
  Signal
  Transmembrane
  Transmembrane helix
• Sequence similarities: Belongs to the Izumo family.
  Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
• Post-translational modification: N-glycosylated. Glycosylation is not essential for fusion and for proper protein trafficking in sperm By similarity. Phosphorylated
• Subunit structure: Monomer, homodimer and homooligomer
• Subcellular location: Membrane; Single-pass type I membrane protein
• Tissue specificity: Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction.
• Miscellaneous: Izumo is the name of a Japanese shrine to marriage.

General information above from UniProt

Function for IZUMO1 Protein

UniProtKB:

IZUMO1 is involved in the fertilization process. IZUMO1 may be involved in the fusion of the sperm with the egg.

Genatlas:

• IZUMO1 is involved in membrane fusion between sperm and egg (essentiel for fusion)
• IZUMO1 is involved in the fertilization process in sperm
• IZUMO1 is membrane protein that is not exposed to the outside of sperm, but is hidden under the plasma membrane before acrosome reaction
• IZUMO1 is membrane protein that is not exposed to the outside of sperm, but is hidden under the plasma membrane before acrosome reaction
• IZUMO1 plays a role in oocyte-spermatozoa fusion failure
• IZUMO1 is sperm protein that is essential for gamete fusion

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