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CD11b/ITGAM/Integrin alpha M  Protein, Antibody, ELISA Kit, cDNA Clone

CD11b/ITGAM/Integrin alpha M Related Area

CD11b/ITGAM/Integrin alpha M Related Pathways

CD11b/ITGAM/Integrin alpha M Summary & Protein Information

CD11b/ITGAM/Integrin alpha M Background

Subunit structure: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3. {ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813}.
Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Predominantly expressed in monocytes and granulocytes.
Involvement in disease: DISEASE: Systemic lupus erythematosus 6 (SLEB6) [MIM:609939]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Sequence similarity: Belongs to the integrin alpha chain family. {ECO:0000305}.; Contains 7 FG-GAP repeats. {ECO:0000305}.; Contains 1 VWFA domain. {ECO:0000255|PROSITE-ProRule:PRU00219}.
General information above from UniProt

CD11b/ITGAM/Integrin alpha M Alternative Name

CR3A,MO1A,CD11B,MAC-1,MAC1A,SLEB6, [homo-sapiens]
CR3,CR3A,MAC1,Cd11b,Ly-40,Mac-1,Mac-1a,CD11b/CD18,F730045J24Rik, [mus-musculus]

CD11b/ITGAM/Integrin alpha M Related Studies

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