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ITGA5 & ITGB1 Heterodimer Antibody, Mouse MAb
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ITGA5 & ITGB1 Heterodimer Antibody, Mouse MAb PDF Download

Catalog   Size (Price) Quantity In Stock Operation
CT014-MM01  

YES   
 

Primary antibody | Secondary antibody | Tag antibody | Isotype control antibody | Loading control antibody | Antibody Purification

ITGA5 & ITGB1 Heterodimer Antibody Datasheet

  Order or Inquire for ITGA5 & ITGB1 Heterodimer Antibody product Quality antibodies Antibody production services
  Detection limit is 0.039 ng/well in ELISA
 

ITGA5 & ITGB1 Heterodimer Antibody Product Information

Immunogen :

Recombinant Human ITGA5 & ITGB1 Heterodimer protein (Catalog#CT014-H2508H)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )

Clone ID :

01

Ig Type :

Mouse IgG1

Formulation : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation :

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ITGA5 & ITGB1 Heterodimer (rh ITGA5 & ITGB1 Heterodimer; Catalog#CT014-H2508H; P08648,  P05556-1; Met 1-Tyr 995, Met 1-Asp 728). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

ITGA5 & ITGB1 Heterodimer Antibody Usage Guide

Specificity :

Human ITGA5 & ITGB1 Heterodimer

 

No cross-reactivity in ELISA with

Human cell lysate (293 cell line)

Direct ELISA : This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human ITGA5 & ITGB1 Heterodimer. The detection limit for Human ITGA5 & ITGB1 Heterodimer is approximately 0.039 ng/well.
Storage : This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

ITGA5 & ITGB1 Heterodimer Antibody Related Products & Topics

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ITGA5 & ITGB1 Heterodimer Antibody Background

Integrin alpha-5, also known as CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, CD49e and ITGA5, is a single-pass type I membrane protein which belongs to theintegrin alpha chain family. ITGA5 contains 7FG-GAP repeats. Integrin alpha-5 / beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Integrin beta-1, also known as Fibronectin receptor subunit beta, VLA-4 subunit beta, CD29 and ITGB1, is a single-pass type I membrane protein which belongs to theintegrin beta chain family. It contains oneVWFA domain. Integrin beta-1 / ITGB1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. It binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5. Integrin beta-1 / ITGB1 interacts with FLNA, FLNB and RANBP9. Integrin beta-1 / ITGB1 binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses.

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen.Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Integrin alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1.

References

  1. Balzac F., et al., 1994, J. Cell Biol. 127:557-565.
  2. Sano H., et al., 2002, J. Biol. Chem. 277:19439-19447.
  3. Chen F.-H., et al., 2005, J. Biol. Chem. 280:32655-32661.
  4. Pellinen T., et al., 2006, J. Cell Biol. 173:767-780.
  5. Chuang N.N., et al., 2007, Biochem. Soc. Trans. 35:1292-1294.
  6. Pellinen T., et al., 2008, Dev. Cell. 15: 371-385.
  7. Choudhary C., et al., 2009, Science. 325: 834-840.
 
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