ISG15 Protein & Antibody

SG15 ubiquitin-like modifier

ISG15 Products

ISG15 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ISG15	Human	G1P2 / ISG15 (mature form) Protein, Recombinant, Native	12729-HNAE1
ISG15	Human	ISG15 / G1P2 Protein, Recombinant, Native	12729-HNAE

ISG15 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human ISG15	WB, ELISA	ISG15 Antibody (Antigen Affinity Purified)	12729-RP02

ISG15 Related Areas

Neuroscience>>Neurodegenerative Disease>>Ubiquitin-proteasome pathway>> ISG15

Enzyme>>Protein Kinase>>Intracellular Kinase>> Jak (Janus Kinase) >> ISG15

ISG15 Alternative Names

G1P2, IFI15, IP17, UCRP, hUCRP[Homo sapiens]

G1p2, IGI15, IP17, Irfp, UCRP[Mus musculus]

ISG15 Background

Interferon-induced 17 kDa protein (ISG15), a 15-kDa protein of unique primary amino acid sequence, functions intracellularly as an ubiquitin homologue and a cytokine that induces production of IFN-gamma and augments NK / lymphokine-activated killer cell proliferation and function. ISG15 is secreted from monocytes and lymphocytes. ISG15 is an ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli. Alterations in the ISG15 signalling pathway have also been found in several human tumour entities. In addition to being stimulated by type I interferon, expression of ISG15 is greatly induced by viral or bacterial infection through the Janus kinase / signal transducer and activator of transcription (Jak / STAT) signalling pathway. After induction, ISG15 is secreted by monocytes, B- and T-lymphocytes and fibroblasts. We demonstrate the novel way in which the function of the ISG15 protein is inhibited by influenza B virus, which strongly induces the ISG15 protein: a specific region of the influenza B virus NS1 protein, which includes part of its effector domain, blocks the covalent linkage of ISG15 to its target proteins both in vitro and in infected cells.

ISG15 Related Studies

1. Cunha J, et al. (1996) In vitro and in vivo secretion of human ISG15, an IFN-induced immunomodulatory cytokine. J Immunol. 157(9): 4100-8.
2. Andersen JB, et al. (2006) The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: friend or foe? Cytokine Growth Factor Rev. 17(6): 411-21.
3. Nuran Bektas, et al. (2008) The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer. Breast Cancer Res. 10(4): 58.