ISG15 (Protein|Antibody|cDNA Clone|ELISA Kit)

All ISG15 reagents are produced in house and quality controlled, including 3 ISG15 Antibody, 17 ISG15 Gene, 2 ISG15 Protein. All ISG15 reagents are ready to use.

Recombinant ISG15 proteins are expressed by E. coli with fusion tags as Native.

ISG15antibodies are validated with different applications, which are WB, ELISA, IHC-P, ICC/IF, IF.

ISG15cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ISG15 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

ISG15 Protein (2)

Species

ISG15 Protein, Human, Recombinant (mature form)

12729-HNAE1

Expression host: E. coli

Human ISG15 Protein 10117

ISG15 Protein, Human, Recombinant

12729-HNAE

Expression host: E. coli

Human ISG15 Protein 10116
Go

ISG15 Antibody (3)

Application Clonality
Host

Anti-ISG15 Antibody

12729-R239

Application: WB,ELISA,ICC/IF,IF

Clonality: MAb

Human ISG15 Immunofluorescence(IF) 2868

Anti-ISG15 Antibody

12729-RP01

Application: ELISA

Clonality: PAb

Anti-ISG15 Antibody

12729-RP02

Application: WB,ELISA,IHC-P

Clonality: PAb

Human ISG15 Immunohistochemistry(IHC) 3725
Go

ISG15 cDNA Clone (17)

Mouse
Human
NM_005101.3

Interferon-induced 17 kDa protein (ISG15), a 15-kDa protein of unique primary amino acid sequence, functions intracellularly as an ubiquitin homologue and a cytokine that induces production of IFN-gamma and augments NK / lymphokine-activated killer cell proliferation and function. ISG15 is secreted from monocytes and lymphocytes. ISG15 is an ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli. Alterations in the ISG15 signalling pathway have also been found in several human tumour entities. In addition to being stimulated by type I interferon, expression of ISG15 is greatly induced by viral or bacterial infection through the Janus kinase / signal transducer and activator of transcription (Jak / STAT) signalling pathway. After induction, ISG15 is secreted by monocytes, B- and T-lymphocytes and fibroblasts. We demonstrate the novel way in which the function of the ISG15 protein is inhibited by influenza B virus, which strongly induces the ISG15 protein: a specific region of the influenza B virus NS1 protein, which includes part of its effector domain, blocks the covalent linkage of ISG15 to its target proteins both in vitro and in infected cells.

Protein
Antibody
Gene
Close