Quick Order

LILRB2/ILT4/LIR-2  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
  • Slide 1
14132-H08H-50
14132-H08H-20
50 µg 
20 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
14132-H02H-50
14132-H02H-100
50 µg 
100 µg 
Add to Cart

LILRB2/ILT4/LIR-2 Related Area

LILRB2/ILT4/LIR-2 Related Pathways

    LILRB2/ILT4/LIR-2 Summary & Protein Information

    LILRB2/ILT4/LIR-2 Background

    Subunit structure: Binds PTPN6 when phosphorylated. Binds FCGR1A.
    Domain: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Tissue specificity: Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.
    Post-translational: Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
    Sequence similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains.C
    General information above from UniProt

    ILT4, also known as LILRB2, is a member of the the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). ILT4 gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Multiple transcript variants encoding different isoforms have been found for ILT4 gene. ILT4 is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

    LILRB2/ILT4/LIR-2 Alternative Name

    LILRB2/ILT4/LIR-2 Related Studies

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"