ILKAP

ILKAP is protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. ILKAP selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. ILKAP inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.

ILKAP Related Areas

Enzyme>>Phosphatase & Regulator>>ILKAP

Signal Transduction>>Phosphatase & Regulator>>ILKAP

ILKAP Alternative Names

ILKAP, DKFZp434J2031, FLJ10181, MGC4846, PP2C-DELTA [Homo sapiens]

Ilkap, 0710007A14Rik, 1600009O09Rik, PP2C-DELTA [Mus musculus]

Summaries for ILKAP

Entrez Gene summary for ILKAP:

The protein encoded by this ILKAP gene is a protein serine/threonine phosphatase of the PP2C family. ILKAP can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, ILKAP may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]

Wikipedia summary for ILKAP:

Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.

Human ILKAP Protein General Information

 

• Protein names: Integrin-linked kinase-associated serine/threonine phosphatase 2C, Short name=ILKAP
• Sequence length: 392 AA.
• Catalytic activity: A phosphoprotein + H2O = a protein + phosphate.
• Sequence similarities: ILKAP belongs to the PP2C family. ILKAP contains 1 PP2C-like domain.
• Cofactor: ILKAP binds 2 magnesium or manganese ions per subunit
• Subunit structure: ILKAP interacts with ILK. Specific association with ILK is independent of the catalytic activity of either partner.
• Subcellular location: Cytoplasm
• Tissue specificity: Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
• Enzyme regulation: Inhibited rather than stimulated by magnesium.

General information above from UniProt

Function for ILKAP Protein

UniProtKB:

ILKAP is protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. ILKAP selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. ILKAP inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.

Genatlas:

• ILKAP plays a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation
• ILKAP acts to control the cross-talk between integrin-induced and TNFalpha-induced signaling pathways, inhibiting the former and stimulating the latter, thereby inhibiting proliferation and survival and promoting the apoptosis of cancer cells (Tamura 2006)
• ILKAP plays an important role in inhibiting oncogenic transformation
• ILKAP functions as tumor suppressor protein, and important physiological regulator of cell growth and of cellular stress signaling (Lammers 2007)
• ILKAP plays key roles in a variety of cell functions, including cell proliferation, adhesion and migration (Nakrieko 2008)
• ILKAP with XPO1, are pivotal modulators of ILK subcellular distribution and activity in the keratinocytes (Nakrieko 2008)

Homology for human ILKAP

• homolog to Drosophila CG5890
• homolog to C.elegans F21A10.1