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ILKAP  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
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ILKAP Related Area

ILKAP Related Pathways

ILKAP Summary & Protein Information

ILKAP Background

Gene Summary: The protein encoded by this ILKAP gene is a protein serine/threonine phosphatase of the PP2C family. ILKAP can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, ILKAP may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]
General information above from NCBI
Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Cofactor: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; ; Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250};
Enzyme regulation: ENZYME REGULATION: Inhibited rather than stimulated by magnesium.
Subunit structure: Interacts with ILK. Specific association with ILK is independent of the catalytic activity of either partner. {ECO:0000269|PubMed:11331582, ECO:0000269|PubMed:14990992}.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11331582}.
Tissue specificity: Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues. {ECO:0000269|PubMed:11331582}.
Sequence similarity: Belongs to the PP2C family. {ECO:0000305}.; Contains 1 PPM-type phosphatase domain. {ECO:0000255|PROSITE-ProRule:PRU01082}.
General information above from UniProt

Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is cytoplasm protein which belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues. ILKAP may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. ILKAP selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. ILKAP inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. Integrin-linked kinase ( ILK ) plays key roles in a variety of cell functions, including cell proliferation, adhesion and migration. Within the cell, ILK localizes to multiple sites, including the cytoplasm, focal adhesion complexes that mediate cell adhesion to extracellular substrates, as well as cell-cell junctions in epidermal keratinocytes. Nuclear ILK can be rapidly exported into the cytoplasm through a CRM1-dependent pathway, and its export is enhanced by the type 2C protein phosphatase ILKAP. Nuclear localization of ILK in epidermal keratinocytes is associated with increased DNA synthesis, which is sensitive to inhibition by ILKAP.

ILKAP Alternative Name

ILKAP2,ILKAP3,PP2C-DELTA, [homo-sapiens]
DKFZp434J2031,FLJ10181,ILKAP,MGC4846,PP2C-DELTA, [human]
0710007A14Rik,1600009O09Rik,Ilkap,PP2C-DELTA, [mouse]
PP2C-DELTA,0710007A14Rik,1600009O09Rik, [mus-musculus]

ILKAP Related Studies

  • Leung-Hagesteijn C. et al., 2001, EMBO J. 20: 2160-70.
  • Kumar,A.S. et al., 2004, Oncogene. 23 (19):3454-61.
  • Lammers,T. et al., 2007, Crit Rev Biochem Mol Biol. 42 (6):437-61.
  • Nakrieko,K.A. et al., 2008, Cell Cycle. 7 (14):2157-66.