IL9R / Interleukin 9 receptor Protein Price Inquiry ( Available Sizes )
IL9R / Interleukin 9 receptor Protein Product Information
||A DNA sequence encoding the rat IL9R / Interleukin 9 receptor (EDM04022.1) extracellular domain (Met 1-Ala 270) was expressed, fused with a polyhistidine tag at the C-terminus.
IL9R / Interleukin 9 receptor Protein QC Testing
||> 90 % as determined by SDS-PAGE.
IL9R / Interleukin 9 receptor protein
||< 1.0 EU per μg of the protein as determined by the LAL method
||Samples are stable for up to twelve months from date of receipt at -70℃
|Predicted N terminal:
||The recombinant rat IL9R / Interleukin 9 receptor comprises 244 amino acids and predicts a molecular mass of 28.2 kDa. The apparent molecular mass of the rat IL9R / Interleukin 9 receptor is approximately 36 kDa in SDS-PAGE under reducing conditions due to glycosylation.
||Lyophilized from sterile PBS , pH 7.4
- Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
- Please contact us for any concerns or special requirements.
IL9R / Interleukin 9 receptor Protein Usage Guide
||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IL9R / Interleukin 9 receptor Protein Related Products & Topics
IL9R / Interleukin 9 receptor Protein Description
Interleukin 9 receptor (IL9R / Interleukin 9 receptor)， also known as CD129 (Cluster of Differentiation 129)， is a type I cytokine receptor. The IL9R / Interleukin 9 receptor is a member of the hemopoietin receptor superfamily and interacts with the gamma chain of the IL-2 receptor for signal transduction. Interleukin-9 (IL-9) exerts its pleiotropic effects through the IL9R / Interleukin 9 receptor complex that consists of the ligand specific IL-9R α-chain, and the IL-2R γ-chain. IL9 is a multifunctional cytokine released by T cells. Various observations indicate that IL-9 is actively involved in mast cells responses by inducing the proliferation and differentiation of these cells. Other potential biological targets for IL-9 include B lymphocytes, and hematopoietic progenitors, for which higher responses were observed with foetal or transformed cells as compared to normal adult progenitors. It has been identified that IL9R / Interleukin 9 receptor is constitutively related with JAk1. Activated STAT complexes induced by IL-9 were found to contain STAT1, STAT3, and STAT5 transcription factors. A single tyrosine of the IL-9 receptor, required for activation of three different STAT proteins, is necessary for distinct activities of this cytokine, including proliferative responses.
- Demoulin JB. et al., 1998, Int Rev Immunol. 16 (3-4): 345-64.
- Sliva D. et al., 1999, Biochem Biophys Res Commun. 263 (1): 149-55.
- Renauld JC. et al., 1995, J Leukoc Biol. 57 (3): 353-60.