Rat IL9R / Interleukin 9 receptor Protein (His Tag) (Cytokine)

Interleukin 9 receptor Protein Datasheet

IL9R / Interleukin 9 receptor Protein Product Information

• Synonym: IL9R
• Protein Construction: A DNA sequence encoding the rat IL9R / Interleukin 9 receptor (EDM04022.1) extracellular domain (Met 1-Ala 270) was expressed, fused with a polyhistidine tag at the C-terminus.
• Source: Rat
• Expression Host: Human Cells

IL9R / Interleukin 9 receptor Protein QC Testing

• Purity: > 90 % as determined by SDS-PAGE.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Val 38
• Molecular Mass: The recombinant rat IL9R / Interleukin 9 receptor comprises 244 amino acids and predicts a molecular mass of 28.2 kDa. The apparent molecular mass of the rat IL9R / Interleukin 9 receptor is approximately 36 kDa in SDS-PAGE under reducing conditions due to glycosylation.
• Formulation: Lyophilized from sterile PBS , pH 7.4
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: IL9R / Interleukin 9 receptor protein

IL9R / Interleukin 9 receptor Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL9R / Interleukin 9 receptor Protein Description

Interleukin 9 receptor (IL9R / Interleukin 9 receptor)， also known as CD129 (Cluster of Differentiation 129)， is a type I cytokine receptor. The IL9R / Interleukin 9 receptor is a member of the hemopoietin receptor superfamily and interacts with the gamma chain of the IL-2 receptor for signal transduction. Interleukin-9 (IL-9) exerts its pleiotropic effects through the IL9R / Interleukin 9 receptor complex that consists of the ligand specific IL-9R α-chain, and the IL-2R γ-chain. IL9 is a multifunctional cytokine released by T cells. Various observations indicate that IL-9 is actively involved in mast cells responses by inducing the proliferation and differentiation of these cells. Other potential biological targets for IL-9 include B lymphocytes, and hematopoietic progenitors, for which higher responses were observed with foetal or transformed cells as compared to normal adult progenitors. It has been identified that IL9R / Interleukin 9 receptor is constitutively related with JAk1. Activated STAT complexes induced by IL-9 were found to contain STAT1, STAT3, and STAT5 transcription factors. A single tyrosine of the IL-9 receptor, required for activation of three different STAT proteins, is necessary for distinct activities of this cytokine, including proliferative responses.

References

1. Demoulin JB. et al., 1998, Int Rev Immunol. 16 (3-4): 345-64.
2. Sliva D. et al., 1999, Biochem Biophys Res Commun. 263 (1): 149-55.
3. Renauld JC. et al., 1995, J Leukoc Biol. 57 (3): 353-60.