- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Interleukin 7 receptor Protein Datasheet
IL7R / IL7RA Protein Price Inquiry ( Available Sizes )
IL7R / IL7RA Protein Product Information
A DNA sequence encoding the rat IL7R (D4A3X8) (Met1-Asp239) was fused with Fc region of mouse IgG at the C-terminus.
|Expression Host:||Human Cells|
IL7R / IL7RA Protein QC Testing
|Purity:||> 95 % as determined by SDS-PAGE||SDS-PAGE:
IL7R / IL7RA protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Glu 21|
The recombinant rat IL7R /mFc comprises 453 amino acids and has a predicted molecular mass of 51.4 kDa. The apparent molecular mass of the protein is approximately 65 in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
IL7R / IL7RA Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
IL7R / IL7RA Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|CD127/IL-7RA||Human||CD127/IL-7RA/Fc Protein, Recombinant||10975-H03H|
|CD127/IL-7RA||Human||CD127/IL-7RA Protein, Recombinant||10975-H08H|
|CD127/IL-7RA||Mouse||CD127/IL-7RA Protein, Recombinant||50090-M08H|
|CD127/IL-7RA||Rat||IL7R / IL7RA Protein, Recombinant||80083-R05H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||Mouse Monoclonal Antibody||10975-MM12|
|WB, ELISA||CD127/IL-7RA Antibody, Rabbit PAb||10975-RP01|
|WB, ELISA||CD127/IL-7RA Antibody, Rabbit PAb (Antigen Affinity Purified)||10975-RP02|
|WB, ELISA||CD127/IL-7RA Antibody, Rabbit PAb (Antigen Affinity Purified)||50090-RP02|
IL7R / IL7RA Protein Description
Interleukin 7 Receptor alpha ( IL-7Rα ), also known as CD127, is a hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7Rα is majorly expressed on T cells and their precursors, and early in B cell development as well, prior to the appearance of surface IgM. Mature human IL-7Rα consists of a 219 aa extracellular domain (ECD) with one fibronectin type-III domain and a WSxWS motif, a 25 aa transmembrane segment, and a 195 aa cytoplasmic domain. Within the ECD, human IL-7Rα shares 67% aa sequence identity with mouse IL-7Rα. Mutations in the human IL-7Rα gene cause a type of severe combined immunodeficiency in which the major deficiencies are in T cell development, whereas B and NK cells are relatively normal in number. Therefore, the IL-7Rα is critically required for the proper development and function of lymphoid cells. In addition to IL-7, IL-7Rα also associates with TSLPR to form the functional receptor for thymic stromal lymphopoietin (TSLP) which indirectly regulates T cell development by modulating dendritic cell activation. Dynamic regulation of IL-7Rα is important for the generation of appropriate immune responses.
- Sudo T. et al., 1993, Proc. Natl Acad Sci. 90: 9125-9.
- Park LS. et al., 2000, J Exp Med. 192: 659-70.
- Pandey A. et al., 2000, Nat Immunol. 1: 59-64.
- Kaech SM. et al., 2003, Nat Immunol. 4: 1191-8.
- Gregory SG. et al., 2007, Nat Genet. 39 (9): 1083-91.
- Mazzucchelli R. et al., 2007, Nat Rev Immunol. 7:144-54.
- Vranjkovic A. et al., 2007, Int Immunol. 19: 1329-39.
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