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Rat IL7R / IL7RA Protein (Fc Tag)
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Rat IL7R / IL7RA Protein (Fc Tag) (Cytokine) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
80083-R05H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Interleukin 7 receptor Protein Datasheet

 

IL7R / IL7RA Protein Price Inquiry ( Available Sizes )

IL7R / IL7RA Protein Product Information

Synonym : IL7R
Protein Construction:

A DNA sequence encoding the rat IL7R (D4A3X8) (Met1-Asp239) was  fused with Fc region of mouse IgG at the C-terminus.

Source: Rat
Expression Host: Human Cells

IL7R / IL7RA Protein QC Testing

Purity: > 95 % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

IL7R / IL7RA protein

Bio-activity:

Measured by its ability to bind rat IL7 (Cat:80329-RNAE) in a functional ELISA.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Glu 21
Molecular Mass:

The recombinant rat IL7R /mFc comprises 453 amino acids and has a predicted molecular mass of 51.4 kDa. The apparent molecular mass of the protein is approximately 65 in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

IL7R / IL7RA Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL7R / IL7RA Protein Related Products & Topics

Related Areas:

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD127/IL-7RA

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>CD127/IL-7RA

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD127/IL-7RA

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CD127/IL-7RA

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells / Regulatory T Cells>>CD127/IL-7RA

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
CD127/IL-7RA Human CD127/IL-7RA/Fc Protein, Recombinant 10975-H03H
CD127/IL-7RA Human CD127/IL-7RA Protein, Recombinant 10975-H08H
CD127/IL-7RA Mouse CD127/IL-7RA Protein, Recombinant 50090-M08H
CD127/IL-7RA Rat IL7R / IL7RA Protein, Recombinant 80083-R05H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
CD127/IL-7RA
WB, ELISA Mouse Monoclonal Antibody 10975-MM12
Human
CD127/IL-7RA
WB, ELISA CD127/IL-7RA Antibody, Rabbit PAb 10975-RP01
Human
CD127/IL-7RA
WB, ELISA CD127/IL-7RA Antibody, Rabbit PAb (Antigen Affinity Purified) 10975-RP02
Mouse
CD127/IL-7RA
WB, ELISA CD127/IL-7RA Antibody, Rabbit PAb (Antigen Affinity Purified) 50090-RP02

IL7R / IL7RA Protein Description

Interleukin 7 Receptor alpha ( IL-7Rα ), also known as CD127, is a hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7Rα is majorly expressed on T cells and their precursors, and early in B cell development as well, prior to the appearance of surface IgM. Mature human IL-7Rα consists of a 219 aa extracellular domain (ECD) with one fibronectin type-III domain and a WSxWS motif, a 25 aa transmembrane segment, and a 195 aa cytoplasmic domain. Within the ECD, human IL-7Rα shares 67% aa sequence identity with mouse IL-7Rα. Mutations in the human IL-7Rα gene cause a type of severe combined immunodeficiency in which the major deficiencies are in T cell development, whereas B and NK cells are relatively normal in number. Therefore, the IL-7Rα is critically required for the proper development and function of lymphoid cells. In addition to IL-7, IL-7Rα also associates with TSLPR to form the functional receptor for thymic stromal lymphopoietin (TSLP) which indirectly regulates T cell development by modulating dendritic cell activation. Dynamic regulation of IL-7Rα is important for the generation of appropriate immune responses.

References

  1. Sudo T. et al., 1993, Proc. Natl Acad Sci. 90: 9125-9.
  2. Park LS. et al., 2000, J Exp Med. 192: 659-70.
  3. Pandey A. et al., 2000, Nat Immunol. 1: 59-64.
  4. Kaech SM. et al., 2003, Nat Immunol. 4: 1191-8.
  5. Gregory SG. et al., 2007, Nat Genet. 39 (9): 1083-91.
  6. Mazzucchelli R. et al., 2007, Nat Rev Immunol. 7:144-54.
  7. Vranjkovic A. et al., 2007, Int Immunol. 19: 1329-39.
 

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