Quick Order

IL7/IL-7/Interleukin-7  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: E. coli  
11821-HNAE-20
11821-HNAE-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
Expression host: E. coli  
50217-MNAE-20
50217-MNAE-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
Expression host: E. coli  
80329-RNAE-20
80329-RNAE-10
20 µg 
10 µg 
Add to Cart
  • Slide 1

IL7/IL-7/Interleukin-7 Related Area

IL7/IL-7/Interleukin-7 Related Pathways

    IL7/IL-7/Interleukin-7 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    IL7/IL-7/Interleukin-7 Summary & Protein Information

    IL7/IL-7/Interleukin-7 Background

    Gene Summary: The protein encoded by this IL7 gene is a cytokine important for B and T cell development. IL7e and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that IL7 plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]
    General information above from NCBI
    Subcellular location: Secreted.
    Sequence similarity: Belongs to the IL-7/IL-9 family. {ECO:0000305}.
    General information above from UniProt

    IL7, also known as interleukin 7, is a hematopoietic growth factor which belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. IL7 stimulates the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. IL7 and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. It is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRß) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    IL7/IL-7/Interleukin-7 Alternative Name

    IL-7, [homo-sapiens]
    IL7,IL-7,interleukin 7, [human]
    A630026I06Rik,hlb368,Il7,Il-7,interleukin 7, [mouse]
    Il-7,hlb368,A630026I06Rik, [mus-musculus]

    IL7/IL-7/Interleukin-7 Related Studies

  • Watanabe M, et al. (1995) Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.
  • J Clin Invest. 95(6):2945-53. Sawa Y, et al. (2009) Hepatic interleukin-7 expression regulates T cell responses. Immunity. 30 (3):447-57.
  • Flad HD, et al. (1996) Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur J Immunol. 26(10): 2541-4.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"